Expression of RTN3 in cancer - Summary - The Human Protein Atlas

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RTN3

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	RTN3
Gene description	Reticulon 3
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in neuronal cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 2 antibodies. HPA015649 , HPA015650
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and renal cancer (favourable).
Liver cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA015649	HPA015650

GENE INFORMATION
Gene name	RTN3 (HGNC Symbol)
Synonyms	ASYIP, HAP, NSPL2, NSPLII, RTN3-A1
Description	Reticulon 3 (HGNC Symbol)
Entrez gene summary	This gene belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1 (BACE1), and the production of amyloid-beta. An increase in the expression of any reticulon protein substantially reduces the production of amyloid-beta, suggesting that reticulon proteins are negative modulators of BACE1 in cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, and pseudogenes of this gene are located on chromosomes 4 and 12. [provided by RefSeq, May 2012]
Chromosome	11
Cytoband	q13.1
Chromosome location (bp)	63681446 - 63759891
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000133318 (version 83.38)
Entrez gene	10313
UniProt	O95197 (UniProt - Evidence at protein level)
neXtProt	NX_O95197
Antibodypedia	RTN3 antibodies

PROTEIN BROWSER

RTN3-001	RTN3-002	RTN3-003	RTN3-005	RTN3-006	RTN3-007	RTN3-009	RTN3-010	RTN3-013	RTN3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RTN3-001 ENSP00000344106 ENST00000339997	O95197 [Direct mapping] Reticulon-3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006915 [apoptotic process] GO:0012505 [endomembrane system] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0016192 [vesicle-mediated transport] GO:0070062 [extracellular exosome] GO:0071786 [endoplasmic reticulum tubular network organization] Show all	1013 aa 110.7 kDa	No	2
RTN3-002 ENSP00000367050 ENST00000377819	O95197 [Direct mapping] Reticulon-3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006915 [apoptotic process] GO:0012505 [endomembrane system] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0016192 [vesicle-mediated transport] GO:0070062 [extracellular exosome] GO:0071786 [endoplasmic reticulum tubular network organization] Show all	1032 aa 112.6 kDa	No	2
RTN3-003 ENSP00000442733 ENST00000540798	O95197 [Direct mapping] Reticulon-3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006915 [apoptotic process] GO:0012505 [endomembrane system] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0016192 [vesicle-mediated transport] GO:0070062 [extracellular exosome] GO:0071786 [endoplasmic reticulum tubular network organization] Show all	920 aa 100.8 kDa	No	2
RTN3-005 ENSP00000440874 ENST00000537981	O95197 [Direct mapping] Reticulon-3 A0A024R5C4 [Target identity:100%; Query identity:100%] Reticulon Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006915 [apoptotic process] GO:0012505 [endomembrane system] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0016192 [vesicle-mediated transport] GO:0070062 [extracellular exosome] GO:0071786 [endoplasmic reticulum tubular network organization] Show all	236 aa 25.6 kDa	No	2
RTN3-006 ENSP00000346492 ENST00000354497	O95197 [Direct mapping] Reticulon-3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006915 [apoptotic process] GO:0012505 [endomembrane system] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0016192 [vesicle-mediated transport] GO:0070062 [extracellular exosome] GO:0071786 [endoplasmic reticulum tubular network organization] Show all	214 aa 23.5 kDa	No	1
RTN3-007 ENSP00000340903 ENST00000341307	O95197 [Direct mapping] Reticulon-3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006915 [apoptotic process] GO:0012505 [endomembrane system] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0016192 [vesicle-mediated transport] GO:0070062 [extracellular exosome] GO:0071786 [endoplasmic reticulum tubular network organization] Show all	241 aa 26.5 kDa	No	2
RTN3-009 ENSP00000442080 ENST00000543552	F5H891 [Direct mapping] Reticulon-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0012505 [endomembrane system] Show all	130 aa 13.3 kDa	No	0
RTN3-010 ENSP00000441614 ENST00000545432	F5GWG7 [Direct mapping] Reticulon-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0012505 [endomembrane system] Show all	136 aa 14 kDa	No	0
RTN3-013 ENSP00000437971 ENST00000542238	F5H617 [Direct mapping] Reticulon Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0012505 [endomembrane system] GO:0016021 [integral component of membrane] Show all	185 aa 19.9 kDa	No	1
RTN3-201 ENSP00000348279 ENST00000356000	O95197 [Direct mapping] Reticulon-3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006915 [apoptotic process] GO:0012505 [endomembrane system] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0016192 [vesicle-mediated transport] GO:0070062 [extracellular exosome] GO:0071786 [endoplasmic reticulum tubular network organization] Show all	255 aa 27.6 kDa	No	2

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