Expression of RARRES3 in cancer - Summary - The Human Protein Atlas

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RARRES3

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	RARRES3
Gene description	Retinoic acid receptor responder (tazarotene induced) 3
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (CAPAN-2, RPTEC TERT1, SK-BR-3)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable), breast cancer (favourable) and cervical cancer (favourable).
Pancreatic cancer p<0.001 Breast cancer p<0.001 Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	RARRES3 (HGNC Symbol)
Synonyms	HRASLS4, TIG3
Description	Retinoic acid receptor responder (tazarotene induced) 3 (HGNC Symbol)
Entrez gene summary	Retinoids exert biologic effects such as potent growth inhibitory and cell differentiation activities and are used in the treatment of hyperproliferative dermatological diseases. These effects are mediated by specific nuclear receptor proteins that are members of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. RARRES1, RARRES2, and RARRES3 are genes whose expression is upregulated by the synthetic retinoid tazarotene. RARRES3 is thought act as a tumor suppressor or growth regulator. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	q12.3
Chromosome location (bp)	63536809 - 63546462
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000133321 (version 83.38)
Entrez gene	5920
UniProt	Q9UL19 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UL19
Antibodypedia	RARRES3 antibodies

PROTEIN BROWSER

RARRES3-001	RARRES3-002	RARRES3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RARRES3-001 ENSP00000255688 ENST00000255688	Q9UL19 [Direct mapping] Retinoic acid receptor responder protein 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004623 [phospholipase A2 activity] GO:0005515 [protein binding] GO:0006644 [phospholipid metabolic process] GO:0008285 [negative regulation of cell proliferation] GO:0016021 [integral component of membrane] GO:0016042 [lipid catabolic process] Show all	164 aa 18.2 kDa	No	1
RARRES3-002 ENSP00000402943 ENST00000439013	Q9UL19 [Direct mapping] Retinoic acid receptor responder protein 3 Show all	Predicted intracellular proteins Show all	GO:0004623 [phospholipase A2 activity] GO:0005515 [protein binding] GO:0006644 [phospholipid metabolic process] GO:0008285 [negative regulation of cell proliferation] GO:0016021 [integral component of membrane] GO:0016042 [lipid catabolic process] Show all	156 aa 17.4 kDa	No	0
RARRES3-201 ENSP00000346431 ENST00000354445	A6NG31 [Direct mapping] Retinoic acid receptor responder protein 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	164 aa 18.2 kDa	No	1

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.