Expression of HRASLS2 in cancer - Summary

GENERAL INFORMATION
Gene name	HRASLS2
Gene description	HRAS-like suppressor 2
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enriched (U-266/70)
HPA (normal tissue):	Tissue enhanced (duodenum, small intestine)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Granular cytoplasmic expression in several tissues, most abundant in glandular cells of the gastrointestinal tract.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification. Caution, targets protein from more than one gene.
Reliability score	Approved based on 1 antibody. HPA058997
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable) and cervical cancer (favourable).
Pancreatic cancer p<0.001 Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

STAINING SUMMARY

HPA058997

GENE INFORMATION
Gene name	HRASLS2 (HGNC Symbol)
Synonyms	FLJ20556
Description	HRAS-like suppressor 2 (HGNC Symbol)
Entrez gene summary
Chromosome	11
Cytoband	q12.3
Chromosome location (bp)	63552770 - 63563383
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000133328 (version 83.38)
Entrez gene	54979
UniProt	Q9NWW9 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NWW9
Antibodypedia	HRASLS2 antibodies

PROTEIN BROWSER

HRASLS2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HRASLS2-001 ENSP00000255695 ENST00000255695	Q9NWW9 [Direct mapping] HRAS-like suppressor 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005737 [cytoplasm] GO:0016021 [integral component of membrane] GO:0016042 [lipid catabolic process] GO:0016746 [transferase activity, transferring acyl groups] GO:0016787 [hydrolase activity] Show all	162 aa 17.4 kDa	No	1