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MYH11

GENERAL INFORMATION

Gene name

 MYH11

Gene description

 Myosin, heavy chain 11, smooth muscle

Protein class

 Cancer-related genes
Candidate cardiovascular disease genes
Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (prostate cancer)
HPA (cell line):Cell line enhanced (BEWO, U-698)
HPA (normal tissue):Tissue enhanced (seminal vesicle, smooth muscle)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Distinct expression in myoepithelial and smooth muscle cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Supported based on 3 antibodies.
HPA014539 , HPA015310 , CAB002302
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (favourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (prostate cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA014539
HPA015310
CAB002302

GENE INFORMATION

Gene name

 MYH11 (HGNC Symbol)

Synonyms

 SMHC, SMMHC

Description

 Myosin, heavy chain 11, smooth muscle (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. The pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript that encodes a protein consisting of the first 165 residues from the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Alternative splicing generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Chromosome

 16

Cytoband

 p13.11

Chromosome location (bp)

 15703135 - 15857033

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000133392 (version 83.38)

Entrez gene

 4629

UniProt

 P35749 (UniProt - Evidence at protein level)

neXtProt

 NX_P35749

Antibodypedia

 MYH11 antibodies

PROTEIN BROWSER
MYH11-001
MYH11-003
MYH11-006
MYH11-013
MYH11-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MYH11-001
ENSP00000300036
ENST00000300036
P35749 [Direct mapping]
Myosin-11
A0A024QZJ4 [Target identity:100%; Query identity:100%]
Myosin, heavy polypeptide 11, smooth muscle, isoform CRA_a
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Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003774 [motor activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0005859 [muscle myosin complex]
GO:0006936 [muscle contraction]
GO:0006939 [smooth muscle contraction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0008307 [structural constituent of muscle]
GO:0016459 [myosin complex]
GO:0030241 [skeletal muscle myosin thick filament assembly]
GO:0032982 [myosin filament]
GO:0042470 [melanosome]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048251 [elastic fiber assembly]
GO:0048739 [cardiac muscle fiber development]
GO:0051015 [actin filament binding]
GO:0070062 [extracellular exosome]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
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 1972 aa
227.3 kDa 		No 0
MYH11-003
ENSP00000458731
ENST00000576790
P35749 [Direct mapping]
Myosin-11
A0A024QZJ6 [Target identity:100%; Query identity:100%]
Myosin, heavy polypeptide 11, smooth muscle, isoform CRA_b
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003774 [motor activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0005859 [muscle myosin complex]
GO:0006936 [muscle contraction]
GO:0006939 [smooth muscle contraction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0008307 [structural constituent of muscle]
GO:0016459 [myosin complex]
GO:0030241 [skeletal muscle myosin thick filament assembly]
GO:0032982 [myosin filament]
GO:0042470 [melanosome]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048251 [elastic fiber assembly]
GO:0048739 [cardiac muscle fiber development]
GO:0051015 [actin filament binding]
GO:0070062 [extracellular exosome]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
Show all
 1938 aa
223.6 kDa 		No 0
MYH11-006
ENSP00000379616
ENST00000396324
P35749 [Direct mapping]
Myosin-11
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003774 [motor activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0005859 [muscle myosin complex]
GO:0006936 [muscle contraction]
GO:0006939 [smooth muscle contraction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0008307 [structural constituent of muscle]
GO:0016459 [myosin complex]
GO:0030241 [skeletal muscle myosin thick filament assembly]
GO:0032982 [myosin filament]
GO:0042470 [melanosome]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048251 [elastic fiber assembly]
GO:0048739 [cardiac muscle fiber development]
GO:0051015 [actin filament binding]
GO:0070062 [extracellular exosome]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
Show all
 1979 aa
228.1 kDa 		No 0
MYH11-013
ENSP00000407821
ENST00000452625
P35749 [Direct mapping]
Myosin-11
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003774 [motor activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0005859 [muscle myosin complex]
GO:0006936 [muscle contraction]
GO:0006939 [smooth muscle contraction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0008307 [structural constituent of muscle]
GO:0016459 [myosin complex]
GO:0030241 [skeletal muscle myosin thick filament assembly]
GO:0032982 [myosin filament]
GO:0042470 [melanosome]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048251 [elastic fiber assembly]
GO:0048739 [cardiac muscle fiber development]
GO:0051015 [actin filament binding]
GO:0070062 [extracellular exosome]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
Show all
 1945 aa
224.3 kDa 		No 0
MYH11-201
ENSP00000484924
ENST00000616439
B1PS43 [Direct mapping]
Myosin heavy chain 11 smooth muscle isoform; Myosin-11
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Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003774 [motor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0008152 [metabolic process]
GO:0016459 [myosin complex]
GO:0051015 [actin filament binding]
Show all
 2029 aa
234.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.