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MED10

GENERAL INFORMATION

Gene name

 MED10

Gene description

 Mediator complex subunit 10

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), renal cancer (unfavourable) and glioma (unfavourable).
Liver cancer p<0.001
Renal cancer p<0.001
Glioma p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 MED10 (HGNC Symbol)

Synonyms

 L6, MGC5309, NUT2, TRG20

Description

 Mediator complex subunit 10 (HGNC Symbol)

Entrez gene summary

 MED10 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM, Oct 2008]

Chromosome

 5

Cytoband

 p15.31

Chromosome location (bp)

 6371881 - 6378594

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000133398 (version 83.38)

Entrez gene

 84246

UniProt

 Q9BTT4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BTT4

Antibodypedia

 MED10 antibodies

PROTEIN BROWSER
MED10-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MED10-001
ENSP00000255764
ENST00000255764
Q9BTT4 [Direct mapping]
Mediator of RNA polymerase II transcription subunit 10
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000151 [ubiquitin ligase complex]
GO:0001104 [RNA polymerase II transcription cofactor activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0010467 [gene expression]
GO:0016567 [protein ubiquitination]
GO:0016592 [mediator complex]
GO:0019827 [stem cell population maintenance]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070847 [core mediator complex]
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 135 aa
15.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.