Expression of ADCK2 in cancer - Summary - The Human Protein Atlas

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ADCK2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ADCK2
Gene description	AarF domain containing kinase 2
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membranous and cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA036036
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA036036

GENE INFORMATION
Gene name	ADCK2 (HGNC Symbol)
Synonyms	MGC20727
Description	AarF domain containing kinase 2 (HGNC Symbol)
Entrez gene summary
Chromosome	7
Cytoband	q34
Chromosome location (bp)	140673153 - 140696261
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000133597 (version 83.38)
Entrez gene	90956
UniProt	Q7Z695 (UniProt - Evidence at transcript level)
neXtProt	NX_Q7Z695
Antibodypedia	ADCK2 antibodies

PROTEIN BROWSER

ADCK2-001	ADCK2-002	ADCK2-004	ADCK2-006	ADCK2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADCK2-001 ENSP00000072869 ENST00000072869	Q7Z695 [Direct mapping] Uncharacterized aarF domain-containing protein kinase 2 A4D1T6 [Target identity:100%; Query identity:100%] AarF domain containing kinase 2; AarF domain containing kinase 2, isoform CRA_a Show all	Enzymes Kinases Atypical kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016021 [integral component of membrane] Show all	626 aa 69 kDa	No	1
ADCK2-002 ENSP00000420512 ENST00000476491	C9JE15 [Direct mapping] Uncharacterized aarF domain-containing protein kinase 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	590 aa 65.1 kDa	No	1
ADCK2-004 ENSP00000417367 ENST00000483369	H7C4I2 [Direct mapping] Uncharacterized aarF domain-containing protein kinase 2 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Show all		470 aa 51.6 kDa	No	0
ADCK2-006 ENSP00000420288 ENST00000473512	H7C5M5 [Direct mapping] Uncharacterized aarF domain-containing protein kinase 2 Show all	Phobius predicted membrane proteins Predicted intracellular proteins Show all		223 aa 24.6 kDa	No	0
ADCK2-201 ENSP00000480996 ENST00000622666	A0A087WXG2 [Direct mapping] Uncharacterized aarF domain-containing protein kinase 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all		407 aa 45.1 kDa	No	1

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.