Expression of AGAP3 in cancer - Summary - The Human Protein Atlas

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AGAP3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	AGAP3
Gene description	ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA012883
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable) and colorectal cancer (unfavourable).
Renal cancer p<0.001 Liver cancer p<0.001 Colorectal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA012883

GENE INFORMATION
Gene name	AGAP3 (HGNC Symbol)
Synonyms	CENTG3
Description	ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 (HGNC Symbol)
Entrez gene summary
Chromosome	7
Cytoband	q36.1
Chromosome location (bp)	151085831 - 151144436
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000133612 (version 83.38)
Entrez gene	116988
UniProt	Q96P47 (UniProt - Evidence at protein level)
neXtProt	NX_Q96P47
Antibodypedia	AGAP3 antibodies

PROTEIN BROWSER

AGAP3-001	AGAP3-002	AGAP3-003	AGAP3-004	AGAP3-005	AGAP3-007	AGAP3-010	AGAP3-016	AGAP3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AGAP3-001 ENSP00000380413 ENST00000397238	Q96P47 [Direct mapping] Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000060 [protein import into nucleus, translocation] GO:0003924 [GTPase activity] GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0031593 [polyubiquitin binding] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043547 [positive regulation of GTPase activity] GO:0046872 [metal ion binding] GO:0071944 [cell periphery] Show all	911 aa 98 kDa	No	0
AGAP3-002 ENSP00000418016 ENST00000463381	Q96P47 [Direct mapping] Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0016020 [membrane] GO:0043547 [positive regulation of GTPase activity] GO:0046872 [metal ion binding] Show all	580 aa 62.8 kDa	No	0
AGAP3-003 ENSP00000418125 ENST00000479901	C9J975 [Direct mapping] Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005525 [GTP binding] GO:0005622 [intracellular] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0015031 [protein transport] GO:0016020 [membrane] Show all	343 aa 36.9 kDa	No	0
AGAP3-004 ENSP00000418921 ENST00000473312	Q96P47 [Direct mapping] Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0043547 [positive regulation of GTPase activity] GO:0046872 [metal ion binding] Show all	396 aa 42.5 kDa	No	0
AGAP3-005 ENSP00000335589 ENST00000335367	E7ESL9 [Direct mapping] Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005525 [GTP binding] GO:0005622 [intracellular] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0015031 [protein transport] GO:0016020 [membrane] Show all	576 aa 61.8 kDa	No	0
AGAP3-007 ENSP00000417910 ENST00000461065	H0Y873 [Direct mapping] Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0043547 [positive regulation of GTPase activity] Show all	404 aa 43.3 kDa	No	0
AGAP3-010 ENSP00000417151 ENST00000469901	H7C4F1 [Direct mapping] Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005525 [GTP binding] GO:0005622 [intracellular] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0016020 [membrane] Show all	194 aa 21.3 kDa	No	0
AGAP3-016 ENSP00000418159 ENST00000468796	H7C4U6 [Direct mapping] Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		177 aa 19.2 kDa	No	0
AGAP3-201 ENSP00000480655 ENST00000622464	Q96P47 [Direct mapping] Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 A0A090N7Y0 [Target identity:100%; Query identity:100%] Centaurin, gamma 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0043547 [positive regulation of GTPase activity] GO:0046872 [metal ion binding] Show all	875 aa 95 kDa	No	0

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The Human Protein Atlas

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