Expression of ACTR3B in cancer - Summary - The Human Protein Atlas

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ACTR3B

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ACTR3B
Gene description	ARP3 actin-related protein 3 homolog B (yeast)
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Uncertain based on 2 antibodies. HPA047016 , HPA051683
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and stomach cancer (favourable).
Renal cancer p<0.001 Stomach cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA047016	HPA051683

GENE INFORMATION
Gene name	ACTR3B (HGNC Symbol)
Synonyms	ARP11, ARP3beta
Description	ARP3 actin-related protein 3 homolog B (yeast) (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the actin-related proteins (ARP), which form multiprotein complexes and share 35-55% amino acid identity with conventional actin. The protein encoded by this gene may have a regulatory role in the actin cytoskeleton and induce cell-shape change and motility. Pseudogenes of this gene are located on chromosomes 2, 4, 10, 16, 22 and Y. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]
Chromosome	7
Cytoband
Chromosome location (bp)	152759749 - 152855378
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000133627 (version 83.38)
Entrez gene	57180
UniProt	Q9P1U1 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9P1U1
Antibodypedia	ACTR3B antibodies

PROTEIN BROWSER

ACTR3B-001	ACTR3B-002	ACTR3B-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ACTR3B-001 ENSP00000256001 ENST00000256001	Q9P1U1 [Direct mapping] Actin-related protein 3B Show all	SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0003779 [actin binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005885 [Arp2/3 protein complex] GO:0008150 [biological_process] GO:0034314 [Arp2/3 complex-mediated actin nucleation] GO:0042995 [cell projection] GO:0070062 [extracellular exosome] Show all	418 aa 47.6 kDa	No	0
ACTR3B-002 ENSP00000380452 ENST00000397282	Q9P1U1 [Direct mapping] Actin-related protein 3B Show all	SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0003779 [actin binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005885 [Arp2/3 protein complex] GO:0008150 [biological_process] GO:0034314 [Arp2/3 complex-mediated actin nucleation] GO:0042995 [cell projection] GO:0070062 [extracellular exosome] Show all	330 aa 37.9 kDa	No	0
ACTR3B-003 ENSP00000367007 ENST00000377776	Q9P1U1 [Direct mapping] Actin-related protein 3B Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0003779 [actin binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005885 [Arp2/3 protein complex] GO:0008150 [biological_process] GO:0034314 [Arp2/3 complex-mediated actin nucleation] GO:0042995 [cell projection] GO:0070062 [extracellular exosome] Show all	348 aa 39.7 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.