Expression of ATP13A3 in cancer - Summary - The Human Protein Atlas

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ATP13A3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ATP13A3
Gene description	ATPase type 13A3
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA029471
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable) and renal cancer (unfavourable).
Pancreatic cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA029471

GENE INFORMATION
Gene name	ATP13A3 (HGNC Symbol)
Synonyms	AFURS1
Description	ATPase type 13A3 (HGNC Symbol)
Entrez gene summary	ATP13A3 is a member of the P-type ATPase family of proteins that transport a variety of cations across membranes. Other P-type ATPases include ATP7B (MIM 606882) and ATP7A (MIM 300011).[supplied by OMIM, Aug 2008]
Chromosome	3
Cytoband	q29
Chromosome location (bp)	194402672 - 194498364
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000133657 (version 83.38)
Entrez gene	79572
UniProt	Q9H7F0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H7F0
Antibodypedia	ATP13A3 antibodies

PROTEIN BROWSER

ATP13A3-001	ATP13A3-003	ATP13A3-004	ATP13A3-010	ATP13A3-201	ATP13A3-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ATP13A3-001 ENSP00000416508 ENST00000439040	Q9H7F0 [Direct mapping] Probable cation-transporting ATPase 13A3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0005524 [ATP binding] GO:0005887 [integral component of plasma membrane] GO:0006812 [cation transport] GO:0006874 [cellular calcium ion homeostasis] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0019829 [cation-transporting ATPase activity] GO:0043231 [intracellular membrane-bounded organelle] GO:0046872 [metal ion binding] GO:0098655 [cation transmembrane transport] Show all	1226 aa 138 kDa	No	>9
ATP13A3-003 ENSP00000410767 ENST00000446356	C9JAP7 [Direct mapping] Probable cation-transporting ATPase 13A3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006812 [cation transport] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] Show all	47 aa 5.4 kDa	No	1
ATP13A3-004 ENSP00000406234 ENST00000457986	C9J7Z7 [Direct mapping] Probable cation-transporting ATPase 13A3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006812 [cation transport] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] Show all	103 aa 12 kDa	No	1
ATP13A3-010 ENSP00000402550 ENST00000429136	H7C1U7 [Direct mapping] Probable cation-transporting ATPase 13A3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	162 aa 18.9 kDa	No	2
ATP13A3-201 ENSP00000256031 ENST00000256031	Q9H7F0 [Direct mapping] Probable cation-transporting ATPase 13A3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0005524 [ATP binding] GO:0005887 [integral component of plasma membrane] GO:0006812 [cation transport] GO:0006874 [cellular calcium ion homeostasis] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0019829 [cation-transporting ATPase activity] GO:0043231 [intracellular membrane-bounded organelle] GO:0046872 [metal ion binding] GO:0098655 [cation transmembrane transport] Show all	1226 aa 138 kDa	No	>9
ATP13A3-202 ENSP00000482200 ENST00000619199	A0A087WYY3 [Direct mapping] Probable cation-transporting ATPase 13A3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0005524 [ATP binding] GO:0006812 [cation transport] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0046872 [metal ion binding] Show all	701 aa 77.4 kDa	No	3

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