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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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SFTPD
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    TISSUE

  • CELL

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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

SFTPD

Gene description

Surfactant protein D

Protein class

Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Tissue enriched (lung cancer)
HPA (cell line):Cell line enhanced (BEWO, hTCEpi)
HPA (normal tissue):Tissue enriched (lung)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in pneumocytes.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 3 antibodies.
HPA044582 , HPA056768 , CAB004578
SHOW MORE

PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Tissue enriched (lung cancer)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA044582
HPA056768
CAB004578

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Few cases of colorectal cancers showed weak membranous staining. A single case of prostate cancer exhibited moderate positivity. Several cases of gliomas and lung cancers displayed weak to moderate cytoplasmic positivity. Remaining cancer tissues were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

A single case of adenocarcinoma of lung showed moderate cytoplasmic positivity. Weak nuclear and cytoplasmic staining was observed in a single case of stomach cancer. All other cancer tissues were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

A single case of adenocarcinoma of lung exhibited moderate cytoplasmic immunoreactivity. All other cancer tissues were negative.

GENE INFORMATION

Gene name

SFTPD (HGNC Symbol)

Synonyms

COLEC7, SFTP4, SP-D

Description

Surfactant protein D (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is part of the innate immune response, protecting the lungs against inhaled microorganisms and chemicals. The encoded protein may also be involved in surfactant metabolism. [provided by RefSeq, Jul 2015]

Chromosome

10

Cytoband

q22.3

Chromosome location (bp)

79937740 - 79982614

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000133661 (version 83.38)

Entrez gene

6441

UniProt

P35247 (UniProt - Evidence at protein level)

neXtProt

NX_P35247

Antibodypedia

SFTPD antibodies

PROTEIN BROWSER

SFTPD-001
SFTPD-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SFTPD-001
ENSP00000361366
ENST00000372292
P35247 [Direct mapping]
Pulmonary surfactant-associated protein D
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001817 [regulation of cytokine production]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005581 [collagen trimer]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005764 [lysosome]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006898 [receptor-mediated endocytosis]
GO:0007585 [respiratory gaseous exchange]
GO:0030139 [endocytic vesicle]
GO:0030246 [carbohydrate binding]
GO:0042130 [negative regulation of T cell proliferation]
GO:0042742 [defense response to bacterium]
GO:0043129 [surfactant homeostasis]
GO:0044267 [cellular protein metabolic process]
GO:0045085 [negative regulation of interleukin-2 biosynthetic process]
GO:0045087 [innate immune response]
GO:0045334 [clathrin-coated endocytic vesicle]
GO:0048246 [macrophage chemotaxis]
GO:0048286 [lung alveolus development]
GO:0050766 [positive regulation of phagocytosis]
GO:0050776 [regulation of immune response]
GO:0072593 [reactive oxygen species metabolic process]
Show all
375 aa
37.7 kDa
Yes 0
SFTPD-002
ENSP00000394325
ENST00000444384
Q5T0M2 [Direct mapping]
Pulmonary surfactant-associated protein D
Show all
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
218 aa
21 kDa
Yes 0

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