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Moderate to strong cytoplasmic and membranous immunoreactivity was displayed in several Hodgkin's lymphomas, colorectal and stomach cancers along with a few ovarian, endometrial, prostate, liver and pancreatic cancers. Remaining cancer cells were weakly stained or negative.
GENE INFORMATION
Gene name
KRAS (HGNC Symbol)
Synonyms
KRAS1, KRAS2
Description
Kirsten rat sarcoma viral oncogene homolog (HGNC Symbol)
Entrez gene summary
This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq, Jul 2008]
Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0001934 [positive regulation of protein phosphorylation] GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0003924 [GTPase activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005622 [intracellular] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0006886 [intracellular protein transport] GO:0006913 [nucleocytoplasmic transport] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007411 [axon guidance] GO:0007596 [blood coagulation] GO:0008284 [positive regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008542 [visual learning] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010628 [positive regulation of gene expression] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0019002 [GMP binding] GO:0019003 [GDP binding] GO:0019221 [cytokine-mediated signaling pathway] GO:0021897 [forebrain astrocyte development] GO:0030036 [actin cytoskeleton organization] GO:0030275 [LRR domain binding] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0032228 [regulation of synaptic transmission, GABAergic] GO:0032403 [protein complex binding] GO:0035022 [positive regulation of Rac protein signal transduction] GO:0035176 [social behavior] GO:0038002 [endocrine signaling] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0043406 [positive regulation of MAP kinase activity] GO:0043524 [negative regulation of neuron apoptotic process] GO:0045087 [innate immune response] GO:0045121 [membrane raft] GO:0045596 [negative regulation of cell differentiation] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048169 [regulation of long-term neuronal synaptic plasticity] GO:0048873 [homeostasis of number of cells within a tissue] GO:0050900 [leukocyte migration] GO:0051000 [positive regulation of nitric-oxide synthase activity] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051146 [striated muscle cell differentiation] GO:0051384 [response to glucocorticoid] GO:0051385 [response to mineralocorticoid] GO:0060441 [epithelial tube branching involved in lung morphogenesis]