Cell atlas - E2F5 - The Human Protein Atlas

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E2F5

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli
	Nucleus

Human cell
	Nucleoli
	Nucleoplasm

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GENERAL INFORMATION
Gene name	E2F5
Gene description	E2F transcription factor 5, p130-binding
Protein class	Cancer-related genes Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins Transcription factors
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleus & nucleoli.
RNA cell category	Cell line enhanced (Daudi, AF22)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (supported), Nucleoli (supported)
Single-cell variation	Single-cell variation in protein expression observed.
Mouse	Localized to the Nucleoplasm in mouse cells.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA055723
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (Daudi, AF22) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleus & nucleoli.

Main location

Nucleus (supported), Nucleoli (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA055723	A-431	Nucleus
	HPA055723	A-431	Nucleoli fibrillar center	Spatial
	HPA055723	PC-3	Nucleus
	HPA055723	PC-3	Nucleoli
	HPA055723	U-2 OS	Nucleus
	HPA055723	U-2 OS	Nucleoli fibrillar center

MOUSE CELLS

Main location

Nucleoplasm

Mouse gene

ENSMUSG00000027552 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA055723	NIH 3T3	Nucleoplasm

GENE INFORMATION
Gene name	E2F5
Synonyms
Description	E2F transcription factor 5, p130-binding (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionarily conserved domains that are present in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein is differentially phosphorylated and is expressed in a wide variety of human tissues. It has higher identity to E2F4 than to other family members. Both this protein and E2F4 interact with tumor suppressor proteins p130 and p107, but not with pRB. Alternative splicing results in multiple variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Chromosome	8
Cytoband	q21.2
Chromosome location (bp)	85177225 - 85217158
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000133740 (version 83.38)
Entrez gene	1875
UniProt	Q15329 (UniProt - Evidence at protein level)
neXtProt	NX_Q15329
Antibodypedia	E2F5 antibodies

PROTEIN BROWSER

E2F5-001	E2F5-002	E2F5-003	E2F5-004	E2F5-005	E2F5-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
E2F5-001 ENSP00000398124 ENST00000416274	Q15329 [Direct mapping] Transcription factor E2F5 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Cancer-related genes Candidate cancer biomarkers Show all	GO:0000278 [mitotic cell cycle] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0008134 [transcription factor binding] GO:0009887 [organ morphogenesis] GO:0010467 [gene expression] GO:0030030 [cell projection organization] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0051726 [regulation of cell cycle] Show all	346 aa 37.6 kDa	No	0
E2F5-002 ENSP00000414312 ENST00000418930	Q15329 [Direct mapping] Transcription factor E2F5 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Cancer-related genes Candidate cancer biomarkers Show all	GO:0000278 [mitotic cell cycle] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005730 [nucleolus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0008134 [transcription factor binding] GO:0010467 [gene expression] GO:0030030 [cell projection organization] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0051726 [regulation of cell cycle] Show all	345 aa 37.5 kDa	No	0
E2F5-003 ENSP00000428606 ENST00000521429	E5RHD4 [Direct mapping] Transcription factor E2F5 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0005730 [nucleolus] GO:0006355 [regulation of transcription, DNA-templated] GO:0051726 [regulation of cell cycle] Show all	173 aa 18.7 kDa	Yes	0
E2F5-004 ENSP00000429120 ENST00000517476	Q15329 [Direct mapping] Transcription factor E2F5 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Cancer-related genes Candidate cancer biomarkers Show all	GO:0000278 [mitotic cell cycle] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005730 [nucleolus] GO:0006351 [transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0008134 [transcription factor binding] GO:0010467 [gene expression] GO:0030030 [cell projection organization] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0051726 [regulation of cell cycle] Show all	185 aa 20.2 kDa	No	0
E2F5-005 ENSP00000430461 ENST00000520225	H0YBW8 [Direct mapping] Transcription factor E2F5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005667 [transcription factor complex] GO:0006355 [regulation of transcription, DNA-templated] GO:0016021 [integral component of membrane] GO:0051726 [regulation of cell cycle] Show all	130 aa 13.9 kDa	No	1
E2F5-006 ENSP00000429669 ENST00000518234	H0YBK0 [Direct mapping] Transcription factor E2F5 Show all	Predicted intracellular proteins Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0005730 [nucleolus] GO:0006355 [regulation of transcription, DNA-templated] GO:0051726 [regulation of cell cycle] Show all	182 aa 19.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.