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ARNTL

GENERAL INFORMATION

Gene name

 ARNTL

Gene description

 Aryl hydrocarbon receptor nuclear translocator-like

Protein class

 Predicted intracellular proteins
Predicted secreted proteins
Transcription factors

Predicted localization

 Intracellular,Secreted

Number of transcripts

 14
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
CAB045962
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Skeletal muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ARNTL (HGNC Symbol)

Synonyms

 bHLHe5, BMAL1, JAP3, MOP3, PASD3

Description

 Aryl hydrocarbon receptor nuclear translocator-like (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

Chromosome

 11

Cytoband

 p15.3

Chromosome location (bp)

 13276652 - 13387266

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000133794 (version 83.38)

Entrez gene

 406

UniProt

 O00327 (UniProt - Evidence at protein level)

neXtProt

 NX_O00327

Antibodypedia

 ARNTL antibodies

PROTEIN BROWSER
«
ARNTL-001
ARNTL-002
ARNTL-003
ARNTL-004
ARNTL-005
ARNTL-008
ARNTL-011
ARNTL-015
ARNTL-016
ARNTL-017
ARNTL-018
ARNTL-019
ARNTL-020
ARNTL-022
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARNTL-001
ENSP00000374357
ENST00000389707
O00327 [Direct mapping]
Aryl hydrocarbon receptor nuclear translocator-like protein 1
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001047 [core promoter binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007283 [spermatogenesis]
GO:0007623 [circadian rhythm]
GO:0016605 [PML body]
GO:0017162 [aryl hydrocarbon receptor binding]
GO:0032007 [negative regulation of TOR signaling]
GO:0032922 [circadian regulation of gene expression]
GO:0033391 [chromatoid body]
GO:0042634 [regulation of hair cycle]
GO:0042753 [positive regulation of circadian rhythm]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043565 [sequence-specific DNA binding]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046983 [protein dimerization activity]
GO:0050767 [regulation of neurogenesis]
GO:0050796 [regulation of insulin secretion]
GO:0051726 [regulation of cell cycle]
GO:0051775 [response to redox state]
GO:0051879 [Hsp90 protein binding]
GO:0070491 [repressing transcription factor binding]
GO:0070888 [E-box binding]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:0090403 [oxidative stress-induced premature senescence]
GO:2000074 [regulation of type B pancreatic cell development]
GO:2000323 [negative regulation of glucocorticoid receptor signaling pathway]
GO:2000772 [regulation of cellular senescence]
GO:2001016 [positive regulation of skeletal muscle cell differentiation]
Show all
 625 aa
68.7 kDa 		No 0
ARNTL-002
ENSP00000385581
ENST00000403510
O00327 [Direct mapping]
Aryl hydrocarbon receptor nuclear translocator-like protein 1
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001047 [core promoter binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007283 [spermatogenesis]
GO:0007623 [circadian rhythm]
GO:0016605 [PML body]
GO:0017162 [aryl hydrocarbon receptor binding]
GO:0032007 [negative regulation of TOR signaling]
GO:0032922 [circadian regulation of gene expression]
GO:0033391 [chromatoid body]
GO:0042634 [regulation of hair cycle]
GO:0042753 [positive regulation of circadian rhythm]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043565 [sequence-specific DNA binding]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046983 [protein dimerization activity]
GO:0050767 [regulation of neurogenesis]
GO:0050796 [regulation of insulin secretion]
GO:0051726 [regulation of cell cycle]
GO:0051775 [response to redox state]
GO:0051879 [Hsp90 protein binding]
GO:0070491 [repressing transcription factor binding]
GO:0070888 [E-box binding]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:0090403 [oxidative stress-induced premature senescence]
GO:2000074 [regulation of type B pancreatic cell development]
GO:2000323 [negative regulation of glucocorticoid receptor signaling pathway]
GO:2000772 [regulation of cellular senescence]
GO:2001016 [positive regulation of skeletal muscle cell differentiation]
Show all
 582 aa
64.1 kDa 		No 0
ARNTL-003
ENSP00000385915
ENST00000401424
O00327 [Direct mapping]
Aryl hydrocarbon receptor nuclear translocator-like protein 1
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001047 [core promoter binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007283 [spermatogenesis]
GO:0007623 [circadian rhythm]
GO:0016605 [PML body]
GO:0017162 [aryl hydrocarbon receptor binding]
GO:0032007 [negative regulation of TOR signaling]
GO:0032922 [circadian regulation of gene expression]
GO:0033391 [chromatoid body]
GO:0042634 [regulation of hair cycle]
GO:0042753 [positive regulation of circadian rhythm]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043565 [sequence-specific DNA binding]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046983 [protein dimerization activity]
GO:0050767 [regulation of neurogenesis]
GO:0050796 [regulation of insulin secretion]
GO:0051726 [regulation of cell cycle]
GO:0051775 [response to redox state]
GO:0051879 [Hsp90 protein binding]
GO:0070491 [repressing transcription factor binding]
GO:0070888 [E-box binding]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:0090403 [oxidative stress-induced premature senescence]
GO:2000074 [regulation of type B pancreatic cell development]
GO:2000323 [negative regulation of glucocorticoid receptor signaling pathway]
GO:2000772 [regulation of cellular senescence]
GO:2001016 [positive regulation of skeletal muscle cell differentiation]
Show all
 583 aa
64.2 kDa 		No 0
ARNTL-004
ENSP00000384517
ENST00000403290
O00327 [Direct mapping]
Aryl hydrocarbon receptor nuclear translocator-like protein 1
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000060 [protein import into nucleus, translocation]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0001047 [core promoter binding]
GO:0001190 [transcriptional activator activity, RNA polymerase II transcription factor binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007283 [spermatogenesis]
GO:0007623 [circadian rhythm]
GO:0016604 [nuclear body]
GO:0016605 [PML body]
GO:0017162 [aryl hydrocarbon receptor binding]
GO:0032007 [negative regulation of TOR signaling]
GO:0032922 [circadian regulation of gene expression]
GO:0033391 [chromatoid body]
GO:0042176 [regulation of protein catabolic process]
GO:0042634 [regulation of hair cycle]
GO:0042753 [positive regulation of circadian rhythm]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043425 [bHLH transcription factor binding]
GO:0043565 [sequence-specific DNA binding]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0050767 [regulation of neurogenesis]
GO:0050796 [regulation of insulin secretion]
GO:0051726 [regulation of cell cycle]
GO:0051775 [response to redox state]
GO:0051879 [Hsp90 protein binding]
GO:0060137 [maternal process involved in parturition]
GO:0070491 [repressing transcription factor binding]
GO:0070888 [E-box binding]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:0090403 [oxidative stress-induced premature senescence]
GO:2000074 [regulation of type B pancreatic cell development]
GO:2000323 [negative regulation of glucocorticoid receptor signaling pathway]
GO:2000772 [regulation of cellular senescence]
GO:2001016 [positive regulation of skeletal muscle cell differentiation]
Show all
 626 aa
68.8 kDa 		No 0
ARNTL-005
ENSP00000385897
ENST00000403482
O00327 [Direct mapping]
Aryl hydrocarbon receptor nuclear translocator-like protein 1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Transcription factors
   Basic domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001047 [core promoter binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007283 [spermatogenesis]
GO:0007623 [circadian rhythm]
GO:0016605 [PML body]
GO:0017162 [aryl hydrocarbon receptor binding]
GO:0032007 [negative regulation of TOR signaling]
GO:0032922 [circadian regulation of gene expression]
GO:0033391 [chromatoid body]
GO:0042634 [regulation of hair cycle]
GO:0042753 [positive regulation of circadian rhythm]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043565 [sequence-specific DNA binding]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046983 [protein dimerization activity]
GO:0050767 [regulation of neurogenesis]
GO:0050796 [regulation of insulin secretion]
GO:0051726 [regulation of cell cycle]
GO:0051775 [response to redox state]
GO:0051879 [Hsp90 protein binding]
GO:0070491 [repressing transcription factor binding]
GO:0070888 [E-box binding]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:0090403 [oxidative stress-induced premature senescence]
GO:2000074 [regulation of type B pancreatic cell development]
GO:2000323 [negative regulation of glucocorticoid receptor signaling pathway]
GO:2000772 [regulation of cellular senescence]
GO:2001016 [positive regulation of skeletal muscle cell differentiation]
Show all
 624 aa
68.8 kDa 		Yes 0
ARNTL-008
ENSP00000436721
ENST00000482049
E9PI92 [Direct mapping]
Aryl hydrocarbon receptor nuclear translocator-like protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0046983 [protein dimerization activity]
Show all
 72 aa
8.4 kDa 		No 0
ARNTL-011
ENSP00000434781
ENST00000531665
E9PNI4 [Direct mapping]
Aryl hydrocarbon receptor nuclear translocator-like protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 60 aa
6.6 kDa 		No 0
ARNTL-015
ENSP00000431566
ENST00000534544
E9PKN1 [Direct mapping]
Aryl hydrocarbon receptor nuclear translocator-like protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 59 aa
6.4 kDa 		No 0
ARNTL-016
ENSP00000434044
ENST00000529050
E9PSD2 [Direct mapping]
Aryl hydrocarbon receptor nuclear translocator-like protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 23 aa
2.5 kDa 		No 0
ARNTL-017
ENSP00000434263
ENST00000529825
E9PRB1 [Direct mapping]
Aryl hydrocarbon receptor nuclear translocator-like protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0046983 [protein dimerization activity]
Show all
 46 aa
5.6 kDa 		No 0
ARNTL-018
ENSP00000436313
ENST00000530357
E9PPV4 [Direct mapping]
Aryl hydrocarbon receptor nuclear translocator-like protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0046983 [protein dimerization activity]
Show all
 141 aa
16.2 kDa 		No 0
ARNTL-019
ENSP00000433540
ENST00000527998
E9PKG7 [Direct mapping]
Aryl hydrocarbon receptor nuclear translocator-like protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 76 aa
8.4 kDa 		No 0
ARNTL-020
ENSP00000431488
ENST00000533520
E9PL54 [Direct mapping]
Aryl hydrocarbon receptor nuclear translocator-like protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0046983 [protein dimerization activity]
Show all
 101 aa
11.4 kDa 		No 0
ARNTL-022
ENSP00000433571
ENST00000529388
E9PKF0 [Direct mapping]
Aryl hydrocarbon receptor nuclear translocator-like protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0046983 [protein dimerization activity]
Show all
 135 aa
15.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.