Expression of AMPD3 in cancer - Summary - The Human Protein Atlas

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AMPD3

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	AMPD3
Gene description	Adenosine monophosphate deaminase 3
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Tissue enhanced (parathyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA047408
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable).
Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

Pancreatic cancer

STAINING SUMMARY

HPA047408

GENE INFORMATION
Gene name	AMPD3
Synonyms
Description	Adenosine monophosphate deaminase 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the AMP deaminase gene family. The encoded protein is a highly regulated enzyme that catalyzes the hydrolytic deamination of adenosine monophosphate to inosine monophosphate, a branch point in the adenylate catabolic pathway. This gene encodes the erythrocyte (E) isoforms, whereas other family members encode isoforms that predominate in muscle (M) and liver (L) cells. Mutations in this gene lead to the clinically asymptomatic, autosomal recessive condition erythrocyte AMP deaminase deficiency. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	p15.4
Chromosome location (bp)	10308313 - 10507579
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000133805 (version 83.38)
Entrez gene	272
UniProt	Q01432 (UniProt - Evidence at protein level)
neXtProt	NX_Q01432
Antibodypedia	AMPD3 antibodies

PROTEIN BROWSER

AMPD3-001	AMPD3-002	AMPD3-003	AMPD3-004	AMPD3-005	AMPD3-014	AMPD3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AMPD3-001 ENSP00000379802 ENST00000396554	Q01432 [Direct mapping] AMP deaminase 3 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003876 [AMP deaminase activity] GO:0005829 [cytosol] GO:0006144 [purine nucleobase metabolic process] GO:0006188 [IMP biosynthetic process] GO:0006196 [AMP catabolic process] GO:0009168 [purine ribonucleoside monophosphate biosynthetic process] GO:0019239 [deaminase activity] GO:0032264 [IMP salvage] GO:0034101 [erythrocyte homeostasis] GO:0043101 [purine-containing compound salvage] GO:0044281 [small molecule metabolic process] GO:0046031 [ADP metabolic process] GO:0046033 [AMP metabolic process] GO:0046034 [ATP metabolic process] GO:0046039 [GTP metabolic process] GO:0046872 [metal ion binding] GO:0055086 [nucleobase-containing small molecule metabolic process] GO:0097009 [energy homeostasis] Show all	776 aa 89.7 kDa	No	0
AMPD3-002 ENSP00000433284 ENST00000524866	E9PLK6 [Direct mapping] AMP deaminase 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003876 [AMP deaminase activity] GO:0032264 [IMP salvage] Show all	267 aa 30.1 kDa	No	0
AMPD3-003 ENSP00000379801 ENST00000396553	Q01432 [Direct mapping] AMP deaminase 3 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003876 [AMP deaminase activity] GO:0005829 [cytosol] GO:0006144 [purine nucleobase metabolic process] GO:0006196 [AMP catabolic process] GO:0009168 [purine ribonucleoside monophosphate biosynthetic process] GO:0019239 [deaminase activity] GO:0032264 [IMP salvage] GO:0043101 [purine-containing compound salvage] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0055086 [nucleobase-containing small molecule metabolic process] Show all	767 aa 88.8 kDa	No	0
AMPD3-004 ENSP00000436987 ENST00000528723	Q01432 [Direct mapping] AMP deaminase 3 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003876 [AMP deaminase activity] GO:0005829 [cytosol] GO:0006144 [purine nucleobase metabolic process] GO:0006196 [AMP catabolic process] GO:0009168 [purine ribonucleoside monophosphate biosynthetic process] GO:0019239 [deaminase activity] GO:0032264 [IMP salvage] GO:0043101 [purine-containing compound salvage] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0055086 [nucleobase-containing small molecule metabolic process] Show all	774 aa 89.5 kDa	No	0
AMPD3-005 ENSP00000431648 ENST00000529507	Q01432 [Direct mapping] AMP deaminase 3 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003876 [AMP deaminase activity] GO:0005829 [cytosol] GO:0006144 [purine nucleobase metabolic process] GO:0006196 [AMP catabolic process] GO:0009168 [purine ribonucleoside monophosphate biosynthetic process] GO:0019239 [deaminase activity] GO:0032264 [IMP salvage] GO:0043101 [purine-containing compound salvage] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0055086 [nucleobase-containing small molecule metabolic process] Show all	767 aa 88.8 kDa	No	0
AMPD3-014 ENSP00000432707 ENST00000532250	E9PPG2 [Direct mapping] AMP deaminase 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003876 [AMP deaminase activity] GO:0032264 [IMP salvage] Show all	111 aa 12.6 kDa	No	0
AMPD3-201 ENSP00000396000 ENST00000444303	Q01432 [Direct mapping] AMP deaminase 3 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003876 [AMP deaminase activity] GO:0005829 [cytosol] GO:0006144 [purine nucleobase metabolic process] GO:0006196 [AMP catabolic process] GO:0009168 [purine ribonucleoside monophosphate biosynthetic process] GO:0019239 [deaminase activity] GO:0032264 [IMP salvage] GO:0043101 [purine-containing compound salvage] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0055086 [nucleobase-containing small molecule metabolic process] Show all	608 aa 71.2 kDa	No	0

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