Cell atlas - SBF2 - The Human Protein Atlas

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SBF2

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Intermediate filaments
	Nucleoplasm

Human cell
	Cytosol
	Intermediate Filaments
	Nucleoplasm

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GENERAL INFORMATION
Gene name	SBF2
Gene description	SET binding factor 2
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the cytosol & intermediate filaments.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)
Additional location	In addition localized to the Intermediate filaments (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA050933
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the cytosol & intermediate filaments.

Main location

Nucleoplasm (approved)

Additional location

Intermediate filaments (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA050933	A-431	Nucleoplasm
	HPA050933	A-431	Cytosol
	HPA050933	A549	Nucleoplasm
	HPA050933	A549	Intermediate filaments
	HPA050933	U-2 OS	Nucleoplasm

GENE INFORMATION
Gene name	SBF2 (HGNC Symbol)
Synonyms	CMT4B2, DENND7B, KIAA1766, MTMR13
Description	SET binding factor 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a pseudophosphatase and member of the myotubularin-related protein family. This gene maps within the CMT4B2 candidate region of chromosome 11p15 and mutations in this gene have been associated with Charcot-Marie-Tooth Disease, type 4B2. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	p15.4
Chromosome location (bp)	9778667 - 10294207
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000133812 (version 83.38)
Entrez gene	81846
UniProt	Q86WG5 (UniProt - Evidence at protein level)
neXtProt	NX_Q86WG5
Antibodypedia	SBF2 antibodies

PROTEIN BROWSER

SBF2-001	SBF2-008	SBF2-009	SBF2-015	SBF2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SBF2-001 ENSP00000256190 ENST00000256190	Q86WG5 [Direct mapping] Myotubularin-related protein 13 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005774 [vacuolar membrane] GO:0016020 [membrane] GO:0017112 [Rab guanyl-nucleotide exchange factor activity] GO:0019208 [phosphatase regulator activity] GO:0019902 [phosphatase binding] GO:0035091 [phosphatidylinositol binding] GO:0042552 [myelination] GO:0042803 [protein homodimerization activity] GO:0043547 [positive regulation of GTPase activity] GO:0051262 [protein tetramerization] Show all	1849 aa 208.5 kDa	No	0
SBF2-008 ENSP00000410478 ENST00000420722	H0Y767 [Direct mapping] Myotubularin-related protein 13 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0019208 [phosphatase regulator activity] GO:0043087 [regulation of GTPase activity] Show all	397 aa 45.3 kDa	No	0
SBF2-009 ENSP00000432643 ENST00000530741	H0YD05 [Direct mapping] Myotubularin-related protein 13 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0019208 [phosphatase regulator activity] GO:0043087 [regulation of GTPase activity] Show all	331 aa 36.5 kDa	No	0
SBF2-015 ENSP00000434620 ENST00000532095	H0YDZ1 [Direct mapping] Myotubularin-related protein 13 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0019208 [phosphatase regulator activity] GO:0043087 [regulation of GTPase activity] Show all	132 aa 15.1 kDa	No	0
SBF2-201 ENSP00000482806 ENST00000617179	A0A087WZP7 [Direct mapping] Myotubularin-related protein 13 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0019208 [phosphatase regulator activity] GO:0043087 [regulation of GTPase activity] Show all	1802 aa 203.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.