Expression of MICAL2 in cancer - Summary - The Human Protein Atlas

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MICAL2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MICAL2
Gene description	Microtubule associated monooxygenase, calponin and LIM domain containing 2
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (U-138 MG)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA030437
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA030437

GENE INFORMATION
Gene name	MICAL2 (HGNC Symbol)
Synonyms	KIAA0750
Description	Microtubule associated monooxygenase, calponin and LIM domain containing 2 (HGNC Symbol)
Entrez gene summary
Chromosome	11
Cytoband	p15.3
Chromosome location (bp)	12094008 - 12263789
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000133816 (version 83.38)
Entrez gene	9645
UniProt	O94851 (UniProt - Evidence at protein level)
neXtProt	NX_O94851
Antibodypedia	MICAL2 antibodies

PROTEIN BROWSER

MICAL2-001	MICAL2-007	MICAL2-008	MICAL2-010	MICAL2-011	MICAL2-023	MICAL2-024	MICAL2-025	MICAL2-026	MICAL2-201	MICAL2-202	MICAL2-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MICAL2-001 ENSP00000256194 ENST00000256194	O94851 [Direct mapping] Protein-methionine sulfoxide oxidase MICAL2 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001947 [heart looping] GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0007010 [cytoskeleton organization] GO:0007507 [heart development] GO:0008270 [zinc ion binding] GO:0010735 [positive regulation of transcription via serum response element binding] GO:0016709 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen] GO:0019417 [sulfur oxidation] GO:0030042 [actin filament depolymerization] GO:0043914 [NADPH:sulfur oxidoreductase activity] GO:0055114 [oxidation-reduction process] GO:0071949 [FAD binding] Show all	1124 aa 126.7 kDa	No	0
MICAL2-007 ENSP00000433965 ENST00000527546	O94851 [Direct mapping] Protein-methionine sulfoxide oxidase MICAL2 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001947 [heart looping] GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0007010 [cytoskeleton organization] GO:0007507 [heart development] GO:0008270 [zinc ion binding] GO:0010735 [positive regulation of transcription via serum response element binding] GO:0016709 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen] GO:0019417 [sulfur oxidation] GO:0030042 [actin filament depolymerization] GO:0043914 [NADPH:sulfur oxidoreductase activity] GO:0055114 [oxidation-reduction process] GO:0071949 [FAD binding] Show all	934 aa 106.2 kDa	No	0
MICAL2-008 ENSP00000434209 ENST00000532179	E9PRE0 [Direct mapping] Protein-methionine sulfoxide oxidase MICAL2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		98 aa 11.1 kDa	No	0
MICAL2-010 ENSP00000433818 ENST00000532420	E9PJB0 [Direct mapping] Protein-methionine sulfoxide oxidase MICAL2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		88 aa 10.2 kDa	No	0
MICAL2-011 ENSP00000434957 ENST00000530823		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		3 aa 0.3 kDa	No	0
MICAL2-023 ENSP00000437229 ENST00000524685	E9PNC3 [Direct mapping] Protein-methionine sulfoxide oxidase MICAL2 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0071949 [FAD binding] Show all	120 aa 13.5 kDa	No	0
MICAL2-024 ENSP00000433509 ENST00000525119	E9PKI3 [Direct mapping] Protein-methionine sulfoxide oxidase MICAL2 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0071949 [FAD binding] Show all	134 aa 15.2 kDa	No	0
MICAL2-025 ENSP00000433357 ENST00000533389	E9PL42 [Direct mapping] Protein-methionine sulfoxide oxidase MICAL2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		102 aa 11.5 kDa	No	0
MICAL2-026 ENSP00000435270 ENST00000526065	E9PJB0 [Direct mapping] Protein-methionine sulfoxide oxidase MICAL2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		88 aa 10.2 kDa	No	0
MICAL2-201 ENSP00000344894 ENST00000342902	O94851 [Direct mapping] Protein-methionine sulfoxide oxidase MICAL2 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001947 [heart looping] GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0007010 [cytoskeleton organization] GO:0007507 [heart development] GO:0008270 [zinc ion binding] GO:0010735 [positive regulation of transcription via serum response element binding] GO:0016709 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen] GO:0019417 [sulfur oxidation] GO:0030042 [actin filament depolymerization] GO:0043914 [NADPH:sulfur oxidoreductase activity] GO:0055114 [oxidation-reduction process] GO:0071949 [FAD binding] Show all	1103 aa 124.3 kDa	No	0
MICAL2-202 ENSP00000368932 ENST00000379612	O94851 [Direct mapping] Protein-methionine sulfoxide oxidase MICAL2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0001947 [heart looping] GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0007010 [cytoskeleton organization] GO:0007507 [heart development] GO:0008270 [zinc ion binding] GO:0010735 [positive regulation of transcription via serum response element binding] GO:0016709 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen] GO:0019417 [sulfur oxidation] GO:0030042 [actin filament depolymerization] GO:0043914 [NADPH:sulfur oxidoreductase activity] GO:0055114 [oxidation-reduction process] GO:0071949 [FAD binding] Show all	976 aa 111.7 kDa	No	2
MICAL2-203 ENSP00000441689 ENST00000537344	O94851 [Direct mapping] Protein-methionine sulfoxide oxidase MICAL2 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001947 [heart looping] GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0007010 [cytoskeleton organization] GO:0007507 [heart development] GO:0008270 [zinc ion binding] GO:0010735 [positive regulation of transcription via serum response element binding] GO:0016709 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen] GO:0019417 [sulfur oxidation] GO:0030042 [actin filament depolymerization] GO:0043914 [NADPH:sulfur oxidoreductase activity] GO:0055114 [oxidation-reduction process] GO:0071949 [FAD binding] Show all	1124 aa 126.7 kDa	No	0

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