Expression of RNF122 in cancer - Summary - The Human Protein Atlas

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RNF122

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	RNF122
Gene description	Ring finger protein 122
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (HEK93, Karpas-707)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Nuclear expression in all tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Sub cellular location is contradicted by external data. Subcellular location is contradicted by limited external data.
Reliability score	Uncertain based on 1 antibody. HPA003888
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), thyroid cancer (unfavourable) and prostate cancer (favourable).
Renal cancer p<0.001 Thyroid cancer p<0.001 Prostate cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA003888

GENE INFORMATION
Gene name	RNF122 (HGNC Symbol)
Synonyms	FLJ12526
Description	Ring finger protein 122 (HGNC Symbol)
Entrez gene summary	The encoded protein contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. The encoded protein is localized to the endoplasmic reticulum and golgi apparatus, and may be associated with cell viability. [provided by RefSeq, Jul 2013]
Chromosome	8
Cytoband	p12
Chromosome location (bp)	33547755 - 33567125
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000133874 (version 83.38)
Entrez gene	79845
UniProt	Q9H9V4 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9H9V4
Antibodypedia	RNF122 antibodies

PROTEIN BROWSER

RNF122-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RNF122-001 ENSP00000256257 ENST00000256257	Q9H9V4 [Direct mapping] RING finger protein 122 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] Show all	155 aa 17.5 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.