Expression of C14orf1 in cancer - Summary - The Human Protein Atlas

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C14orf1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	C14orf1
Gene description	Chromosome 14 open reading frame 1
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA043172
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA043172

GENE INFORMATION
Gene name	C14orf1 (HGNC Symbol)
Synonyms	ERG28, NET51
Description	Chromosome 14 open reading frame 1 (HGNC Symbol)
Entrez gene summary
Chromosome	14
Cytoband	q24.3
Chromosome location (bp)	75649791 - 75661189
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000133935 (version 83.38)
Entrez gene	11161
UniProt	Q9UKR5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UKR5
Antibodypedia	C14orf1 antibodies

PROTEIN BROWSER

C14orf1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
C14orf1-001 ENSP00000256319 ENST00000256319	Q9UKR5 [Direct mapping] Probable ergosterol biosynthetic protein 28 Q6FII3 [Target identity:100%; Query identity:100%] C14orf1 protein; Chromosome 14 open reading frame 1, isoform CRA_a; cDNA, FLJ92025 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005789 [endoplasmic reticulum membrane] GO:0008150 [biological_process] GO:0016021 [integral component of membrane] GO:0016126 [sterol biosynthetic process] GO:0030133 [transport vesicle] Show all	140 aa 15.9 kDa	No	4

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.