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LOXL2

GENERAL INFORMATION

Gene name

 LOXL2

Gene description

 Lysyl oxidase-like 2

Protein class

 Enzymes
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (smooth muscle)
GTEx:Expressed in all
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
CAB025848
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (smooth muscle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 LOXL2 (HGNC Symbol)

Synonyms

 WS9-14

Description

 Lysyl oxidase-like 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008]

Chromosome

 8

Cytoband

 p21.3

Chromosome location (bp)

 23297189 - 23425328

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000134013 (version 83.38)

Entrez gene

 4017

UniProt

 Q9Y4K0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y4K0

Antibodypedia

 LOXL2 antibodies

PROTEIN BROWSER
LOXL2-001
LOXL2-005
LOXL2-009
LOXL2-010
LOXL2-012
LOXL2-013
LOXL2-014
LOXL2-016

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LOXL2-001
ENSP00000373783
ENST00000389131
Q9Y4K0 [Direct mapping]
Lysyl oxidase homolog 2
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Enzymes
   ENZYME proteins
   Oxidoreductases
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0001837 [epithelial to mesenchymal transition]
GO:0001935 [endothelial cell proliferation]
GO:0002040 [sprouting angiogenesis]
GO:0003682 [chromatin binding]
GO:0003714 [transcription corepressor activity]
GO:0004720 [protein-lysine 6-oxidase activity]
GO:0005044 [scavenger receptor activity]
GO:0005507 [copper ion binding]
GO:0005515 [protein binding]
GO:0005604 [basement membrane]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0006351 [transcription, DNA-templated]
GO:0006464 [cellular protein modification process]
GO:0006898 [receptor-mediated endocytosis]
GO:0007155 [cell adhesion]
GO:0007568 [aging]
GO:0009055 [electron carrier activity]
GO:0016020 [membrane]
GO:0016570 [histone modification]
GO:0016641 [oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor]
GO:0018277 [protein deamination]
GO:0030199 [collagen fibril organization]
GO:0032332 [positive regulation of chondrocyte differentiation]
GO:0035064 [methylated histone binding]
GO:0043542 [endothelial cell migration]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046688 [response to copper ion]
GO:0055114 [oxidation-reduction process]
GO:0070492 [oligosaccharide binding]
Show all
 774 aa
86.7 kDa 		Yes 0
LOXL2-005
ENSP00000427907
ENST00000520349
H0YAR1 [Direct mapping]
Lysyl oxidase homolog 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005044 [scavenger receptor activity]
GO:0006898 [receptor-mediated endocytosis]
GO:0016020 [membrane]
Show all
 207 aa
22.3 kDa 		No 0
LOXL2-009
ENSP00000429778
ENST00000520871
E5RHH3 [Direct mapping]
Lysyl oxidase homolog 2
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005044 [scavenger receptor activity]
GO:0006898 [receptor-mediated endocytosis]
GO:0016020 [membrane]
Show all
 218 aa
23.8 kDa 		No 0
LOXL2-010
ENSP00000428933
ENST00000519243
E5RFE2 [Direct mapping]
Lysyl oxidase homolog 2
Show all
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005044 [scavenger receptor activity]
GO:0006898 [receptor-mediated endocytosis]
GO:0016020 [membrane]
Show all
 96 aa
10.9 kDa 		Yes 0
LOXL2-012
ENSP00000428497
ENST00000524168
E5RI22 [Direct mapping]
Lysyl oxidase homolog 2
Show all
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005044 [scavenger receptor activity]
GO:0006898 [receptor-mediated endocytosis]
GO:0016020 [membrane]
Show all
 139 aa
15.5 kDa 		Yes 0
LOXL2-013
ENSP00000430519
ENST00000518083
E5RJL2 [Direct mapping]
Lysyl oxidase homolog 2
Show all
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005044 [scavenger receptor activity]
GO:0006898 [receptor-mediated endocytosis]
GO:0016020 [membrane]
Show all
 151 aa
16.8 kDa 		Yes 0
LOXL2-014
ENSP00000427883
ENST00000524144
E5RFY0 [Direct mapping]
Lysyl oxidase homolog 2
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005044 [scavenger receptor activity]
GO:0006898 [receptor-mediated endocytosis]
GO:0016020 [membrane]
Show all
 258 aa
27.8 kDa 		No 0
LOXL2-016
ENSP00000473322
ENST00000523833
R4GMS2 [Direct mapping]
Lysyl oxidase homolog 2
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 101 aa
11.2 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.