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ELP3

GENERAL INFORMATION

Gene name

 ELP3

Gene description

 Elongator acetyltransferase complex subunit 3

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 11
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA025812
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and colorectal cancer (favourable).
Renal cancer p<0.001
Colorectal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA025812

GENE INFORMATION

Gene name

 ELP3 (HGNC Symbol)

Synonyms

 FLJ10422, KAT9

Description

 Elongator acetyltransferase complex subunit 3 (HGNC Symbol)

Entrez gene summary

 ELP3 is the catalytic subunit of the histone acetyltransferase elongator complex, which contributes to transcript elongation and also regulates the maturation of projection neurons (Creppe et al., 2009 [PubMed 19185337]).[supplied by OMIM, Apr 2009]

Chromosome

 8

Cytoband

 p21.1

Chromosome location (bp)

 28089673 - 28191156

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000134014 (version 83.38)

Entrez gene

 55140

UniProt

 Q9H9T3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H9T3

Antibodypedia

 ELP3 antibodies

PROTEIN BROWSER
«
ELP3-001
ELP3-003
ELP3-007
ELP3-008
ELP3-009
ELP3-010
ELP3-011
ELP3-017
ELP3-018
ELP3-201
ELP3-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ELP3-001
ENSP00000256398
ENST00000256398
Q9H9T3 [Direct mapping]
Elongator complex protein 3
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000123 [histone acetyltransferase complex]
GO:0000993 [RNA polymerase II core binding]
GO:0001764 [neuron migration]
GO:0002098 [tRNA wobble uridine modification]
GO:0003824 [catalytic activity]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006325 [chromatin organization]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0007417 [central nervous system development]
GO:0008023 [transcription elongation factor complex]
GO:0008080 [N-acetyltransferase activity]
GO:0008607 [phosphorylase kinase regulator activity]
GO:0010484 [H3 histone acetyltransferase activity]
GO:0010485 [H4 histone acetyltransferase activity]
GO:0030335 [positive regulation of cell migration]
GO:0033588 [Elongator holoenzyme complex]
GO:0043966 [histone H3 acetylation]
GO:0043967 [histone H4 acetylation]
GO:0045859 [regulation of protein kinase activity]
GO:0046872 [metal ion binding]
GO:0051536 [iron-sulfur cluster binding]
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 547 aa
62.3 kDa 		No 0
ELP3-003
ENSP00000429180
ENST00000524103
B4DKA4 [Direct mapping]
Elongator complex protein 3; cDNA FLJ58009, highly similar to Homo sapiens elongation protein 3 homolog (ELP3), mRNA; cDNA, FLJ78952, highly similar to Homo sapiens elongation protein 3 homolog (ELP3), mRNA
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   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0002098 [tRNA wobble uridine modification]
GO:0003824 [catalytic activity]
GO:0008080 [N-acetyltransferase activity]
GO:0051536 [iron-sulfur cluster binding]
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 475 aa
54.2 kDa 		No 0
ELP3-007
ENSP00000429248
ENST00000520288
E5RIZ7 [Direct mapping]
Elongator complex protein 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0002098 [tRNA wobble uridine modification]
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 134 aa
14.8 kDa 		No 0
ELP3-008
ENSP00000429573
ENST00000521099
E5RHY2 [Direct mapping]
Elongator complex protein 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0002098 [tRNA wobble uridine modification]
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 106 aa
11.5 kDa 		No 0
ELP3-009
ENSP00000429446
ENST00000520270
E5RIC0 [Direct mapping]
Elongator complex protein 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0002098 [tRNA wobble uridine modification]
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 113 aa
12.4 kDa 		No 0
ELP3-010
ENSP00000428449
ENST00000521015
Q9H9T3 [Direct mapping]
Elongator complex protein 3
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000123 [histone acetyltransferase complex]
GO:0000993 [RNA polymerase II core binding]
GO:0001764 [neuron migration]
GO:0002098 [tRNA wobble uridine modification]
GO:0003824 [catalytic activity]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006325 [chromatin organization]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0007417 [central nervous system development]
GO:0008023 [transcription elongation factor complex]
GO:0008080 [N-acetyltransferase activity]
GO:0008607 [phosphorylase kinase regulator activity]
GO:0010484 [H3 histone acetyltransferase activity]
GO:0010485 [H4 histone acetyltransferase activity]
GO:0030335 [positive regulation of cell migration]
GO:0033588 [Elongator holoenzyme complex]
GO:0043966 [histone H3 acetylation]
GO:0043967 [histone H4 acetylation]
GO:0045859 [regulation of protein kinase activity]
GO:0046872 [metal ion binding]
GO:0051536 [iron-sulfur cluster binding]
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 533 aa
60.6 kDa 		No 0
ELP3-011
ENSP00000428532
ENST00000521570
E5RHR2 [Direct mapping]
Elongator complex protein 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0002098 [tRNA wobble uridine modification]
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 191 aa
21.5 kDa 		No 0
ELP3-017
ENSP00000427833
ENST00000523357
H0YAP7 [Direct mapping]
Elongator complex protein 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0002098 [tRNA wobble uridine modification]
GO:0008080 [N-acetyltransferase activity]
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 140 aa
15.9 kDa 		No 0
ELP3-018
ENSP00000430942
ENST00000517975
H0YC54 [Direct mapping]
Elongator complex protein 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0002098 [tRNA wobble uridine modification]
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 66 aa
7.8 kDa 		No 0
ELP3-201
ENSP00000369711
ENST00000380353
Q9H9T3 [Direct mapping]
Elongator complex protein 3
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000123 [histone acetyltransferase complex]
GO:0000993 [RNA polymerase II core binding]
GO:0001764 [neuron migration]
GO:0002098 [tRNA wobble uridine modification]
GO:0003824 [catalytic activity]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006325 [chromatin organization]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0007417 [central nervous system development]
GO:0008023 [transcription elongation factor complex]
GO:0008080 [N-acetyltransferase activity]
GO:0008607 [phosphorylase kinase regulator activity]
GO:0010484 [H3 histone acetyltransferase activity]
GO:0010485 [H4 histone acetyltransferase activity]
GO:0030335 [positive regulation of cell migration]
GO:0033588 [Elongator holoenzyme complex]
GO:0043966 [histone H3 acetylation]
GO:0043967 [histone H4 acetylation]
GO:0045859 [regulation of protein kinase activity]
GO:0046872 [metal ion binding]
GO:0051536 [iron-sulfur cluster binding]
Show all
 455 aa
52.2 kDa 		No 0
ELP3-202
ENSP00000445558
ENST00000537665
Q9H9T3 [Direct mapping]
Elongator complex protein 3
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000123 [histone acetyltransferase complex]
GO:0000993 [RNA polymerase II core binding]
GO:0001764 [neuron migration]
GO:0002098 [tRNA wobble uridine modification]
GO:0003824 [catalytic activity]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006325 [chromatin organization]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0007417 [central nervous system development]
GO:0008023 [transcription elongation factor complex]
GO:0008080 [N-acetyltransferase activity]
GO:0008607 [phosphorylase kinase regulator activity]
GO:0010484 [H3 histone acetyltransferase activity]
GO:0010485 [H4 histone acetyltransferase activity]
GO:0030335 [positive regulation of cell migration]
GO:0033588 [Elongator holoenzyme complex]
GO:0043966 [histone H3 acetylation]
GO:0043967 [histone H4 acetylation]
GO:0045859 [regulation of protein kinase activity]
GO:0046872 [metal ion binding]
GO:0051536 [iron-sulfur cluster binding]
Show all
 428 aa
49.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.