Expression of CTIF in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CTIF
Gene description	CBP80/20-dependent translation initiation factor
Protein class	Predicted intracellular proteins Transporters
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression at variable levels in several different cell types.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 2 antibodies. HPA016865 , HPA024801
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA016865	HPA024801

GENE INFORMATION
Gene name	CTIF (HGNC Symbol)
Synonyms	KIAA0427
Description	CBP80/20-dependent translation initiation factor (HGNC Symbol)
Entrez gene summary	CTIF is a component of the CBP80 (NCBP1; MIM 600469)/CBP20 (NCBP2; MIM 605133) translation initiation complex that binds cotranscriptionally to the cap end of nascent mRNA. The CBP80/CBP20 complex is involved in a simultaneous editing and translation step that recognizes premature termination codons (PTCs) in mRNAs and directs PTC-containing mRNAs toward nonsense-mediated decay (NMD). On mRNAs without PTCs, the CBP80/CBP20 complex is replaced with cytoplasmic mRNA cap-binding proteins, including EIF4G (MIM 600495), and steady-state translation of the mRNAs resumes in the cytoplasm (Kim et al., 2009 [PubMed 19648179]).[supplied by OMIM, Dec 2009]
Chromosome	18
Cytoband	q21.1
Chromosome location (bp)	48539046 - 48863217
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000134030 (version 83.38)
Entrez gene	9811
UniProt	O43310 (UniProt - Evidence at protein level)
neXtProt	NX_O43310
Antibodypedia	CTIF antibodies

PROTEIN BROWSER

CTIF-001	CTIF-003	CTIF-004	CTIF-005	CTIF-006	CTIF-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CTIF-001 ENSP00000256413 ENST00000256413	O43310 [Direct mapping] CBP80/20-dependent translation initiation factor A0A024R259 [Target identity:100%; Query identity:100%] KIAA0427, isoform CRA_a Show all	Transporters Transporter channels and pores Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay] GO:0003723 [RNA binding] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006446 [regulation of translational initiation] GO:0048471 [perinuclear region of cytoplasm] Show all	598 aa 67.6 kDa	No	0
CTIF-003 ENSP00000372459 ENST00000382998	O43310 [Direct mapping] CBP80/20-dependent translation initiation factor Show all	Transporters Transporter channels and pores Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay] GO:0003723 [RNA binding] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006446 [regulation of translational initiation] GO:0048471 [perinuclear region of cytoplasm] Show all	600 aa 67.8 kDa	No	0
CTIF-004 ENSP00000467425 ENST00000591387	K7EPK6 [Direct mapping] CBP80/20-dependent translation initiation factor Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		138 aa 15.3 kDa	No	0
CTIF-005 ENSP00000465405 ENST00000587752	K7EK08 [Direct mapping] CBP80/20-dependent translation initiation factor Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] Show all	194 aa 21.8 kDa	No	0
CTIF-006 ENSP00000467957 ENST00000588345	K7EQS5 [Direct mapping] CBP80/20-dependent translation initiation factor Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		104 aa 11.3 kDa	No	0
CTIF-007 ENSP00000467965 ENST00000591412	K7EQS9 [Direct mapping] CBP80/20-dependent translation initiation factor Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		120 aa 13 kDa	No	0