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MRPS36

GENERAL INFORMATION

Gene name

 MRPS36

Gene description

 Mitochondrial ribosomal protein S36

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA035802
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA035802

GENE INFORMATION

Gene name

 MRPS36 (HGNC Symbol)

Synonyms

 DC47, MRP-S36

Description

 Mitochondrial ribosomal protein S36 (HGNC Symbol)

Entrez gene summary

 Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. The mitochondrial ribosome (mitoribosome) consists of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. Pseudogenes corresponding to this gene are found on chromosomes 3p, 4q, 8p, 11q, 12q, and 20p. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 q13.2

Chromosome location (bp)

 69217760 - 69230129

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000134056 (version 83.38)

Entrez gene

 92259

UniProt

 P82909 (UniProt - Evidence at protein level)

neXtProt

 NX_P82909

Antibodypedia

 MRPS36 antibodies

PROTEIN BROWSER
MRPS36-001
MRPS36-002
MRPS36-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MRPS36-001
ENSP00000256441
ENST00000256441
P82909 [Direct mapping]
28S ribosomal protein S36, mitochondrial
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003735 [structural constituent of ribosome]
GO:0004591 [oxoglutarate dehydrogenase (succinyl-transferring) activity]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005763 [mitochondrial small ribosomal subunit]
GO:0006103 [2-oxoglutarate metabolic process]
GO:0006412 [translation]
GO:0006996 [organelle organization]
GO:0009353 [mitochondrial oxoglutarate dehydrogenase complex]
GO:0032543 [mitochondrial translation]
GO:0055114 [oxidation-reduction process]
GO:0070124 [mitochondrial translational initiation]
GO:0070125 [mitochondrial translational elongation]
GO:0070126 [mitochondrial translational termination]
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 103 aa
11.5 kDa 		No 0
MRPS36-002
ENSP00000423659
ENST00000512880
D6R941 [Direct mapping]
28S ribosomal protein S36, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 38 aa
4.5 kDa 		No 0
MRPS36-007
ENSP00000473310
ENST00000602380
D6R941 [Direct mapping]
28S ribosomal protein S36, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 38 aa
4.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.