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The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites. [provided by RefSeq, Jul 2008]
Transporters Transporter channels and pores SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0000922 [spindle pole] GO:0000942 [condensed nuclear chromosome outer kinetochore] GO:0001556 [oocyte maturation] GO:0001701 [in utero embryonic development] GO:0001933 [negative regulation of protein phosphorylation] GO:0005113 [patched binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0006461 [protein complex assembly] GO:0006468 [protein phosphorylation] GO:0007077 [mitotic nuclear envelope disassembly] GO:0007080 [mitotic metaphase plate congression] GO:0007283 [spermatogenesis] GO:0009612 [response to mechanical stimulus] GO:0009636 [response to toxic substance] GO:0010629 [negative regulation of gene expression] GO:0016020 [membrane] GO:0016301 [kinase activity] GO:0019901 [protein kinase binding] GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0031442 [positive regulation of mRNA 3'-end processing] GO:0033129 [positive regulation of histone phosphorylation] GO:0035173 [histone kinase activity] GO:0042246 [tissue regeneration] GO:0042493 [response to drug] GO:0043148 [mitotic spindle stabilization] GO:0045787 [positive regulation of cell cycle] GO:0045931 [positive regulation of mitotic cell cycle] GO:0046680 [response to DDT] GO:0048146 [positive regulation of fibroblast proliferation] GO:0048565 [digestive tract development] GO:0051301 [cell division] GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition] GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051726 [regulation of cell cycle] GO:0051987 [positive regulation of attachment of spindle microtubules to kinetochore] GO:0055015 [ventricular cardiac muscle cell development] GO:0060045 [positive regulation of cardiac muscle cell proliferation] GO:0060623 [regulation of chromosome condensation] GO:0071283 [cellular response to iron(III) ion] GO:0071398 [cellular response to fatty acid] GO:0071407 [cellular response to organic cyclic compound] GO:0071456 [cellular response to hypoxia] GO:0090266 [regulation of mitotic cell cycle spindle assembly checkpoint] GO:2000775 [histone H3-S10 phosphorylation involved in chromosome condensation]
Transporters Transporter channels and pores SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014)
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GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0000922 [spindle pole] GO:0000942 [condensed nuclear chromosome outer kinetochore] GO:0005113 [patched binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0007077 [mitotic nuclear envelope disassembly] GO:0007080 [mitotic metaphase plate congression] GO:0019901 [protein kinase binding] GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0043148 [mitotic spindle stabilization] GO:0045931 [positive regulation of mitotic cell cycle] GO:0051301 [cell division] GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition] GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051726 [regulation of cell cycle] GO:0051987 [positive regulation of attachment of spindle microtubules to kinetochore] GO:0090266 [regulation of mitotic cell cycle spindle assembly checkpoint]