Expression of CD180 in cancer - Summary - The Human Protein Atlas

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CD180

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CD180
Gene description	CD180 molecule
Protein class	CD markers Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Group enriched (Daudi, Karpas-707, U-266/70, U-266/84, U-698)
HPA (normal tissue):	Tissue enhanced (lymph node, tonsil)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in a subset of immune cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA003740
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA003740

GENE INFORMATION
Gene name	CD180 (HGNC Symbol)
Synonyms	LY64, Ly78, RP105
Description	CD180 molecule (HGNC Symbol)
Entrez gene summary	CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	q12.3
Chromosome location (bp)	67179613 - 67196799
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000134061 (version 83.38)
Entrez gene	4064
UniProt	Q99467 (UniProt - Evidence at protein level)
neXtProt	NX_Q99467
Antibodypedia	CD180 antibodies

PROTEIN BROWSER

CD180-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CD180-001 ENSP00000256447 ENST00000256447	Q99467 [Direct mapping] CD180 antigen Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002322 [B cell proliferation involved in immune response] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006954 [inflammatory response] GO:0016021 [integral component of membrane] GO:0031666 [positive regulation of lipopolysaccharide-mediated signaling pathway] GO:0045087 [innate immune response] GO:0071222 [cellular response to lipopolysaccharide] Show all	661 aa 74.2 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.