Some malignant lymphomas displayed moderate to strong cytoplasmic immunoreactivity. Positive inflammatory cells were observed in tumor stroma. Remaining malignant cells were negative.
CD180 (HGNC Symbol)
LY64, Ly78, RP105
CD180 molecule (HGNC Symbol)
Entrez gene summary
CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria. [provided by RefSeq, Jul 2008]