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IRAK2

GENERAL INFORMATION

Gene name

 IRAK2

Gene description

 Interleukin-1 receptor-associated kinase 2

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (BEWO, BJ hTERT+, CAPAN-2, RT4)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and membranous expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA050520 , CAB013483
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (favourable), pancreatic cancer (unfavourable) and liver cancer (unfavourable).
Urothelial cancer p<0.001
Pancreatic cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA050520
CAB013483

GENE INFORMATION

Gene name

 IRAK2

Synonyms

Description

 Interleukin-1 receptor-associated kinase 2 (HGNC Symbol)

Entrez gene summary

 IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 p25.3

Chromosome location (bp)

 10164865 - 10243743

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000134070 (version 83.38)

Entrez gene

 3656

UniProt

 O43187 (UniProt - Evidence at protein level)

neXtProt

 NX_O43187

Antibodypedia

 IRAK2 antibodies

PROTEIN BROWSER
IRAK2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IRAK2-001
ENSP00000256458
ENST00000256458
O43187 [Direct mapping]
Interleukin-1 receptor-associated kinase-like 2
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Enzymes
   Kinases
   TKL Ser/Thr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
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GO:0000187 [activation of MAPK activity]
GO:0001959 [regulation of cytokine-mediated signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0007254 [JNK cascade]
GO:0010008 [endosome membrane]
GO:0031663 [lipopolysaccharide-mediated signaling pathway]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042803 [protein homodimerization activity]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0045087 [innate immune response]
GO:0046982 [protein heterodimerization activity]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]
GO:0070498 [interleukin-1-mediated signaling pathway]
GO:0070555 [response to interleukin-1]
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 625 aa
69.4 kDa 		No 0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
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