Expression of CAMK1 in cancer - Summary - The Human Protein Atlas

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CAMK1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CAMK1
Gene description	Calcium/calmodulin-dependent protein kinase I
Protein class	Enzymes Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (HMC-1)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA051409 , CAB031904
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA051409	CAB031904

GENE INFORMATION
Gene name	CAMK1 (HGNC Symbol)
Synonyms	CaMKI
Description	Calcium/calmodulin-dependent protein kinase I (HGNC Symbol)
Entrez gene summary	Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin-dependent protein kinase cascade. Calcium/calmodulin directly activates calcium/calmodulin-dependent protein kinase I by binding to the enzyme and indirectly promotes the phosphorylation and synergistic activation of the enzyme by calcium/calmodulin-dependent protein kinase I kinase. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	p25.3
Chromosome location (bp)	9757342 - 9769992
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000134072 (version 83.38)
Entrez gene	8536
UniProt	Q14012 (UniProt - Evidence at protein level)
neXtProt	NX_Q14012
Antibodypedia	CAMK1 antibodies

PROTEIN BROWSER

CAMK1-001	CAMK1-005	CAMK1-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CAMK1-001 ENSP00000256460 ENST00000256460	Q14012 [Direct mapping] Calcium/calmodulin-dependent protein kinase type 1 B0YIY3 [Target identity:100%; Query identity:100%] Calcium/calmodulin-dependent protein kinase I, isoform CRA_a; Calcium/calmodulin-dependent protein kinase type 1; cDNA, FLJ95825, Homo sapiens calcium/calmodulin-dependent protein kinase I (CAMK1),mRNA Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0006913 [nucleocytoplasmic transport] GO:0007049 [cell cycle] GO:0007165 [signal transduction] GO:0010976 [positive regulation of neuron projection development] GO:0032091 [negative regulation of protein binding] GO:0032880 [regulation of protein localization] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0043393 [regulation of protein binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046827 [positive regulation of protein export from nucleus] GO:0051147 [regulation of muscle cell differentiation] GO:0051149 [positive regulation of muscle cell differentiation] GO:0051835 [positive regulation of synapse structural plasticity] GO:0060143 [positive regulation of syncytium formation by plasma membrane fusion] GO:0060999 [positive regulation of dendritic spine development] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:1901985 [positive regulation of protein acetylation] Show all	370 aa 41.3 kDa	No	1
CAMK1-005 ENSP00000393238 ENST00000421120	H7C071 [Direct mapping] Calcium/calmodulin-dependent protein kinase type 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	260 aa 28.5 kDa	No	1
CAMK1-006 ENSP00000404587 ENST00000411972	C9JES6 [Direct mapping] Calcium/calmodulin-dependent protein kinase type 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	122 aa 14 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.