Expression of THUMPD3 in cancer - Summary - The Human Protein Atlas

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THUMPD3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	THUMPD3
Gene description	THUMP domain containing 3
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA036170 , HPA036171
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and renal cancer (favourable).
Liver cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

Urothelial cancer

STAINING SUMMARY

HPA036170	HPA036171

GENE INFORMATION
Gene name	THUMPD3 (HGNC Symbol)
Synonyms	DKFZP434F091
Description	THUMP domain containing 3 (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband	p25.3
Chromosome location (bp)	9362842 - 9386791
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000134077 (version 83.38)
Entrez gene	25917
UniProt	Q9BV44 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BV44
Antibodypedia	THUMPD3 antibodies

PROTEIN BROWSER

THUMPD3-001	THUMPD3-002	THUMPD3-003	THUMPD3-004	THUMPD3-005	THUMPD3-006	THUMPD3-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
THUMPD3-001 ENSP00000339532 ENST00000345094	Q9BV44 [Direct mapping] THUMP domain-containing protein 3 A0A024R2F4 [Target identity:100%; Query identity:100%] THUMP domain containing 3, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0008168 [methyltransferase activity] GO:0032259 [methylation] Show all	507 aa 57 kDa	No	0
THUMPD3-002 ENSP00000395893 ENST00000452837	Q9BV44 [Direct mapping] THUMP domain-containing protein 3 A0A024R2F4 [Target identity:100%; Query identity:100%] THUMP domain containing 3, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0008168 [methyltransferase activity] GO:0032259 [methylation] Show all	507 aa 57 kDa	No	0
THUMPD3-003 ENSP00000424064 ENST00000515662	Q9BV44 [Direct mapping] THUMP domain-containing protein 3 A0A024R2F4 [Target identity:100%; Query identity:100%] THUMP domain containing 3, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0008168 [methyltransferase activity] GO:0032259 [methylation] Show all	507 aa 57 kDa	No	0
THUMPD3-004 ENSP00000402968 ENST00000417036	C9JP31 [Direct mapping] THUMP domain-containing protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		41 aa 4.5 kDa	No	0
THUMPD3-005 ENSP00000411126 ENST00000419437	C9J9V2 [Direct mapping] THUMP domain-containing protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		123 aa 13.8 kDa	No	0
THUMPD3-006 ENSP00000412199 ENST00000416603	H7C3J3 [Direct mapping] THUMP domain-containing protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] Show all	269 aa 30.2 kDa	No	0
THUMPD3-009 ENSP00000396359 ENST00000441127	H7C0R6 [Direct mapping] THUMP domain-containing protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] Show all	232 aa 25.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.