Expression of CNTN6 in cancer - Summary - The Human Protein Atlas

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CNTN6

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CNTN6
Gene description	Contactin 6
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (renal cancer, thyroid cancer)
HPA (cell line):	Group enriched (AF22, SH-SY5Y)
HPA (normal tissue):	Tissue enhanced (lung, thyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, most abundant in thyroid gland.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Uncertain based on 1 antibody. HPA016645
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (renal cancer, thyroid cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA016645

GENE INFORMATION
Gene name	CNTN6 (HGNC Symbol)
Synonyms	NB-3
Description	Contactin 6 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Chromosome	3
Cytoband	p26.3
Chromosome location (bp)	1092576 - 1404217
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000134115 (version 83.38)
Entrez gene	27255
UniProt	Q9UQ52 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UQ52
Antibodypedia	CNTN6 antibodies

PROTEIN BROWSER

CNTN6-001	CNTN6-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CNTN6-001 ENSP00000407822 ENST00000446702	Q9UQ52 [Direct mapping] Contactin-6 A0A024R2C7 [Target identity:100%; Query identity:100%] Contactin 6, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007219 [Notch signaling pathway] GO:0007411 [axon guidance] GO:0007417 [central nervous system development] GO:0031225 [anchored component of membrane] Show all	1028 aa 114 kDa	Yes	1
CNTN6-004 ENSP00000341882 ENST00000350110	Q9UQ52 [Direct mapping] Contactin-6 A0A024R2C7 [Target identity:100%; Query identity:100%] Contactin 6, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007219 [Notch signaling pathway] GO:0007411 [axon guidance] GO:0007417 [central nervous system development] GO:0031225 [anchored component of membrane] Show all	1028 aa 114 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.