Expression of DPH6 in cancer - Summary - The Human Protein Atlas

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DPH6

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DPH6
Gene description	Diphthamine biosynthesis 6
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several different tissues at variable levels.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA042976
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA042976

GENE INFORMATION
Gene name	DPH6 (HGNC Symbol)
Synonyms	ATPBD4, MGC14798
Description	Diphthamine biosynthesis 6 (HGNC Symbol)
Entrez gene summary
Chromosome	15
Cytoband	q14
Chromosome location (bp)	35217345 - 35546193
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000134146 (version 83.38)
Entrez gene	89978
UniProt	Q7L8W6 (UniProt - Evidence at protein level)
neXtProt	NX_Q7L8W6
Antibodypedia	DPH6 antibodies

PROTEIN BROWSER

DPH6-001	DPH6-002	DPH6-004	DPH6-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DPH6-001 ENSP00000256538 ENST00000256538	Q7L8W6 [Direct mapping] Diphthine--ammonia ligase Show all	Enzymes ENZYME proteins Ligase Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0017178 [diphthine-ammonia ligase activity] GO:0017183 [peptidyl-diphthamide biosynthetic process from peptidyl-histidine] GO:0031647 [regulation of protein stability] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:1903955 [positive regulation of protein targeting to mitochondrion] Show all	267 aa 30.3 kDa	No	0
DPH6-002 ENSP00000406976 ENST00000440392	Q7L8W6 [Direct mapping] Diphthine--ammonia ligase Show all	Enzymes ENZYME proteins Ligase Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0017178 [diphthine-ammonia ligase activity] GO:0017183 [peptidyl-diphthamide biosynthetic process from peptidyl-histidine] GO:0031647 [regulation of protein stability] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:1903955 [positive regulation of protein targeting to mitochondrion] Show all	165 aa 18.7 kDa	No	0
DPH6-004 ENSP00000453967 ENST00000561411	H0YND7 [Direct mapping] Diphthine--ammonia ligase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		169 aa 19.5 kDa	No	0
DPH6-009 ENSP00000454015 ENST00000558266	H0YNH5 [Direct mapping] Diphthine--ammonia ligase Show all	MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		155 aa 17.9 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.