Cell atlas - GSTM1 - The Human Protein Atlas

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GSTM1

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria

Human cell
	Mitochondria

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GENERAL INFORMATION
Gene name	GSTM1
Gene description	Glutathione S-transferase mu 1
Protein class	Cancer-related genes Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the mitochondria. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Cell line enhanced (MOLT-4, HEL, HeLa)
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA048652
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (MOLT-4, HEL, HeLa) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the mitochondria. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Mitochondria (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA048652	A-431	Mitochondria
	HPA048652	U-2 OS	Mitochondria
	HPA048652	U-251 MG	Mitochondria

GENE INFORMATION
Gene name	GSTM1 (HGNC Symbol)
Synonyms	GST1, H-B, MU
Description	Glutathione S-transferase mu 1 (HGNC Symbol)
Entrez gene summary	Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p13.3
Chromosome location (bp)	109687814 - 109709039
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000134184 (version 83.38)
Entrez gene	2944
UniProt	P09488 (UniProt - Evidence at protein level)
neXtProt	NX_P09488
Antibodypedia	GSTM1 antibodies

PROTEIN BROWSER

GSTM1-001	GSTM1-002	GSTM1-003	GSTM1-004	GSTM1-007	GSTM1-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GSTM1-001 ENSP00000311469 ENST00000309851	P09488 [Direct mapping] Glutathione S-transferase Mu 1 X5DR03 [Target identity:100%; Query identity:100%] Glutathione S-transferase mu 1 isoform B Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004364 [glutathione transferase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006749 [glutathione metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0018916 [nitrobenzene metabolic process] GO:0019899 [enzyme binding] GO:0042178 [xenobiotic catabolic process] GO:0042803 [protein homodimerization activity] GO:0043295 [glutathione binding] GO:0044281 [small molecule metabolic process] GO:0070458 [cellular detoxification of nitrogen compound] GO:1901687 [glutathione derivative biosynthetic process] Show all	218 aa 25.7 kDa	No	0
GSTM1-002 ENSP00000234981 ENST00000349334	P09488 [Direct mapping] Glutathione S-transferase Mu 1 X5D932 [Target identity:100%; Query identity:100%] Glutathione S-transferase mu 1 isoform C Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004364 [glutathione transferase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006749 [glutathione metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0018916 [nitrobenzene metabolic process] GO:0019899 [enzyme binding] GO:0042178 [xenobiotic catabolic process] GO:0042803 [protein homodimerization activity] GO:0043295 [glutathione binding] GO:0044281 [small molecule metabolic process] GO:0070458 [cellular detoxification of nitrogen compound] GO:1901687 [glutathione derivative biosynthetic process] Show all	181 aa 21.3 kDa	No	0
GSTM1-003 ENSP00000358838 ENST00000369823	E7EWW9 [Direct mapping] Glutathione S-transferase Mu 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004364 [glutathione transferase activity] GO:0005515 [protein binding] GO:0008152 [metabolic process] Show all	237 aa 27.6 kDa	No	0
GSTM1-004 ENSP00000358834 ENST00000369819	B9ZVX7 [Direct mapping] Glutathione S-transferase Mu 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004364 [glutathione transferase activity] GO:0005515 [protein binding] GO:0008152 [metabolic process] Show all	149 aa 17.4 kDa	No	0
GSTM1-007 ENSP00000455929 ENST00000483399	H3BQT3 [Direct mapping] Glutathione S-transferase Mu 1; Glutathione S-transferase mu 1 isoform E Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004364 [glutathione transferase activity] GO:0005515 [protein binding] GO:0008152 [metabolic process] Show all	85 aa 10.4 kDa	No	0
GSTM1-008 ENSP00000456315 ENST00000476065	H3BRM6 [Direct mapping] Glutathione S-transferase Mu 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004364 [glutathione transferase activity] GO:0005515 [protein binding] GO:0008152 [metabolic process] Show all	102 aa 12 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.