Expression of REG4 in cancer - Summary - The Human Protein Atlas

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REG4

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	REG4
Gene description	Regenerating islet-derived family, member 4
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (colorectal cancer, pancreatic cancer, stomach cancer)
HPA (cell line):	Group enriched (PC-3, RT4)
HPA (normal tissue):	Group enriched (colon, duodenum, rectum, small intestine)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective expression in goblet cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA046555 , CAB025867
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (colorectal cancer, pancreatic cancer, stomach cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA046555	CAB025867

GENE INFORMATION
Gene name	REG4 (HGNC Symbol)
Synonyms	GISP, REG-IV, RELP
Description	Regenerating islet-derived family, member 4 (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	p12
Chromosome location (bp)	119794018 - 119811660
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000134193 (version 83.38)
Entrez gene	83998
UniProt	Q9BYZ8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BYZ8
Antibodypedia	REG4 antibodies

PROTEIN BROWSER

REG4-001	REG4-002	REG4-004	REG4-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
REG4-001 ENSP00000256585 ENST00000256585	Q9BYZ8 [Direct mapping] Regenerating islet-derived protein 4 A0A024R0M1 [Target identity:100%; Query identity:100%] Regenerating islet-derived family, member 4, isoform CRA_c Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0008201 [heparin binding] GO:2001065 [mannan binding] Show all	158 aa 18.2 kDa	Yes	0
REG4-002 ENSP00000346158 ENST00000354219	Q9BYZ8 [Direct mapping] Regenerating islet-derived protein 4 A0A024R0M1 [Target identity:100%; Query identity:100%] Regenerating islet-derived family, member 4, isoform CRA_c Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0008201 [heparin binding] GO:2001065 [mannan binding] Show all	158 aa 18.2 kDa	Yes	0
REG4-004 ENSP00000358409 ENST00000369401	Q9BYZ8 [Direct mapping] Regenerating islet-derived protein 4 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0008201 [heparin binding] GO:2001065 [mannan binding] Show all	134 aa 15 kDa	Yes	0
REG4-005 ENSP00000437135 ENST00000530654	E9PNV6 [Direct mapping] Regenerating islet-derived protein 4 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		103 aa 11.6 kDa	Yes	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.