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PSRC1

GENERAL INFORMATION

Gene name

 PSRC1

Gene description

 Proline/serine-rich coiled-coil 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Tissue enhanced (cerebral cortex)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in a group of tissues, most abundant in Purkinje cells of cerebellum

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA049315
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA049315

GENE INFORMATION

Gene name

 PSRC1 (HGNC Symbol)

Synonyms

 DDA3

Description

 Proline/serine-rich coiled-coil 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a proline-rich protein that is a target for regulation by the tumor suppressor protein p53. The encoded protein plays an important role in mitosis by recruiting and regulating microtubule depolymerases that destabalize microtubules. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Apr 2014]

Chromosome

 1

Cytoband

 p13.3

Chromosome location (bp)

 109279556 - 109283186

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000134222 (version 83.38)

Entrez gene

 84722

UniProt

 Q6PGN9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6PGN9

Antibodypedia

 PSRC1 antibodies

PROTEIN BROWSER
PSRC1-001
PSRC1-002
PSRC1-003
PSRC1-005
PSRC1-006
PSRC1-007
PSRC1-009
PSRC1-010
PSRC1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PSRC1-001
ENSP00000358923
ENST00000369907
Q6PGN9 [Direct mapping]
Proline/serine-rich coiled-coil protein 1
A0A024R099 [Target identity:100%; Query identity:100%]
Proline/serine-rich coiled-coil 1, isoform CRA_c
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000922 [spindle pole]
GO:0001578 [microtubule bundle formation]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005876 [spindle microtubule]
GO:0007080 [mitotic metaphase plate congression]
GO:0008017 [microtubule binding]
GO:0015630 [microtubule cytoskeleton]
GO:0030308 [negative regulation of cell growth]
GO:0030496 [midbody]
GO:0031116 [positive regulation of microtubule polymerization]
GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0051301 [cell division]
GO:0060236 [regulation of mitotic spindle organization]
Show all
 333 aa
35.6 kDa 		No 0
PSRC1-002
ENSP00000358920
ENST00000369904
Q6PGN9 [Direct mapping]
Proline/serine-rich coiled-coil protein 1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000922 [spindle pole]
GO:0001578 [microtubule bundle formation]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005876 [spindle microtubule]
GO:0007080 [mitotic metaphase plate congression]
GO:0008017 [microtubule binding]
GO:0015630 [microtubule cytoskeleton]
GO:0030308 [negative regulation of cell growth]
GO:0030496 [midbody]
GO:0031116 [positive regulation of microtubule polymerization]
GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0051301 [cell division]
GO:0060236 [regulation of mitotic spindle organization]
Show all
 310 aa
33.6 kDa 		No 0
PSRC1-003
ENSP00000474667
ENST00000409138
Q6PGN9 [Direct mapping]
Proline/serine-rich coiled-coil protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000922 [spindle pole]
GO:0001578 [microtubule bundle formation]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005876 [spindle microtubule]
GO:0007080 [mitotic metaphase plate congression]
GO:0008017 [microtubule binding]
GO:0015630 [microtubule cytoskeleton]
GO:0030308 [negative regulation of cell growth]
GO:0030496 [midbody]
GO:0031116 [positive regulation of microtubule polymerization]
GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0051301 [cell division]
GO:0060236 [regulation of mitotic spindle organization]
Show all
 363 aa
38.8 kDa 		No 0
PSRC1-005
ENSP00000387791
ENST00000429031
Q5T2Z1 [Direct mapping]
Proline/serine-rich coiled-coil protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
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 232 aa
25.1 kDa 		No 0
PSRC1-006
ENSP00000413186
ENST00000418914
Q5T2Z0 [Direct mapping]
Proline/serine-rich coiled-coil protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
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 205 aa
22.3 kDa 		No 0
PSRC1-007
ENSP00000474682
ENST00000474126
S4R3S8 [Direct mapping]
Proline/serine-rich coiled-coil protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 123 aa
12.5 kDa 		No 0
PSRC1-009
ENSP00000386323
ENST00000409267
Q6PGN9 [Direct mapping]
Proline/serine-rich coiled-coil protein 1
A0A024R099 [Target identity:100%; Query identity:100%]
Proline/serine-rich coiled-coil 1, isoform CRA_c
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000922 [spindle pole]
GO:0001578 [microtubule bundle formation]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005876 [spindle microtubule]
GO:0007080 [mitotic metaphase plate congression]
GO:0008017 [microtubule binding]
GO:0015630 [microtubule cytoskeleton]
GO:0030308 [negative regulation of cell growth]
GO:0030496 [midbody]
GO:0031116 [positive regulation of microtubule polymerization]
GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0051301 [cell division]
GO:0060236 [regulation of mitotic spindle organization]
Show all
 333 aa
35.6 kDa 		No 0
PSRC1-010
ENSP00000358919
ENST00000369903
Q6PGN9 [Direct mapping]
Proline/serine-rich coiled-coil protein 1
A0A024R099 [Target identity:100%; Query identity:100%]
Proline/serine-rich coiled-coil 1, isoform CRA_c
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000922 [spindle pole]
GO:0001578 [microtubule bundle formation]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005876 [spindle microtubule]
GO:0007080 [mitotic metaphase plate congression]
GO:0008017 [microtubule binding]
GO:0015630 [microtubule cytoskeleton]
GO:0030308 [negative regulation of cell growth]
GO:0030496 [midbody]
GO:0031116 [positive regulation of microtubule polymerization]
GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0051301 [cell division]
GO:0060236 [regulation of mitotic spindle organization]
Show all
 333 aa
35.6 kDa 		No 0
PSRC1-201
ENSP00000358925
ENST00000369909
Q6PGN9 [Direct mapping]
Proline/serine-rich coiled-coil protein 1
A0A024R099 [Target identity:100%; Query identity:100%]
Proline/serine-rich coiled-coil 1, isoform CRA_c
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000922 [spindle pole]
GO:0001578 [microtubule bundle formation]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005876 [spindle microtubule]
GO:0007080 [mitotic metaphase plate congression]
GO:0008017 [microtubule binding]
GO:0009987 [cellular process]
GO:0015630 [microtubule cytoskeleton]
GO:0030308 [negative regulation of cell growth]
GO:0030496 [midbody]
GO:0031116 [positive regulation of microtubule polymerization]
GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0051301 [cell division]
GO:0060236 [regulation of mitotic spindle organization]
Show all
 333 aa
35.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.