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SORT1

GENERAL INFORMATION

Gene name

 SORT1

Gene description

 Sortilin 1

Protein class

 Disease related genes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues, including epididymis and CNS.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA006889 , CAB011498
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PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (favourable) and liver cancer (unfavourable).
Colorectal cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Melanoma

STAINING SUMMARY
HPA006889
CAB011498

GENE INFORMATION

Gene name

 SORT1 (HGNC Symbol)

Synonyms

 Gp95, NT3

Description

 Sortilin 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the VPS10-related sortilin family of proteins. The encoded preproprotein is proteolytically processed by furin to generate the mature receptor. This receptor plays a role in the trafficking of different proteins to either the cell surface, or subcellular compartments such as lysosomes and endosomes. Expression levels of this gene may influence the risk of myocardial infarction in human patients. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

Chromosome

 1

Cytoband

 p13.3

Chromosome location (bp)

 109309568 - 109397951

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000134243 (version 83.38)

Entrez gene

 6272

UniProt

 Q99523 (UniProt - Evidence at protein level)

neXtProt

 NX_Q99523

Antibodypedia

 SORT1 antibodies

PROTEIN BROWSER
SORT1-001
SORT1-007
SORT1-008
SORT1-009
SORT1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SORT1-001
ENSP00000256637
ENST00000256637
Q99523 [Direct mapping]
Sortilin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001503 [ossification]
GO:0005515 [protein binding]
GO:0005765 [lysosomal membrane]
GO:0005769 [early endosome]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005905 [coated pit]
GO:0006895 [Golgi to endosome transport]
GO:0006897 [endocytosis]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007218 [neuropeptide signaling pathway]
GO:0007275 [multicellular organismal development]
GO:0008333 [endosome to lysosome transport]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0010465 [nerve growth factor receptor activity]
GO:0010468 [regulation of gene expression]
GO:0014902 [myotube differentiation]
GO:0016021 [integral component of membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016050 [vesicle organization]
GO:0019899 [enzyme binding]
GO:0030136 [clathrin-coated vesicle]
GO:0030140 [trans-Golgi network transport vesicle]
GO:0030379 [neurotensin receptor activity, non-G-protein coupled]
GO:0030425 [dendrite]
GO:0031965 [nuclear membrane]
GO:0032509 [endosome transport via multivesicular body sorting pathway]
GO:0032580 [Golgi cisterna membrane]
GO:0032868 [response to insulin]
GO:0038180 [nerve growth factor signaling pathway]
GO:0043025 [neuronal cell body]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0046323 [glucose import]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048227 [plasma membrane to endosome transport]
GO:0048406 [nerve growth factor binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051005 [negative regulation of lipoprotein lipase activity]
GO:1904037 [positive regulation of epithelial cell apoptotic process]
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 831 aa
92.1 kDa 		Yes 1
SORT1-007
ENSP00000487712
ENST00000482236
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 60 aa
6.6 kDa 		No 0
SORT1-008
ENSP00000488262
ENST00000493736
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 119 aa
13.4 kDa 		No 0
SORT1-009
ENSP00000488662
ENST00000633956
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 20 aa
2.4 kDa 		No 0
SORT1-201
ENSP00000438597
ENST00000538502
Q99523 [Direct mapping]
Sortilin
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001503 [ossification]
GO:0005515 [protein binding]
GO:0005765 [lysosomal membrane]
GO:0005769 [early endosome]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005905 [coated pit]
GO:0006895 [Golgi to endosome transport]
GO:0006897 [endocytosis]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007218 [neuropeptide signaling pathway]
GO:0007275 [multicellular organismal development]
GO:0008333 [endosome to lysosome transport]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0010465 [nerve growth factor receptor activity]
GO:0010468 [regulation of gene expression]
GO:0014902 [myotube differentiation]
GO:0016021 [integral component of membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016050 [vesicle organization]
GO:0019899 [enzyme binding]
GO:0030136 [clathrin-coated vesicle]
GO:0030379 [neurotensin receptor activity, non-G-protein coupled]
GO:0031965 [nuclear membrane]
GO:0032509 [endosome transport via multivesicular body sorting pathway]
GO:0032580 [Golgi cisterna membrane]
GO:0032868 [response to insulin]
GO:0038180 [nerve growth factor signaling pathway]
GO:0046323 [glucose import]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048227 [plasma membrane to endosome transport]
GO:0048406 [nerve growth factor binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051005 [negative regulation of lipoprotein lipase activity]
Show all
 694 aa
77.4 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.