Expression of ADAM30 in cancer - Summary - The Human Protein Atlas

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ADAM30

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ADAM30
Gene description	ADAM metallopeptidase domain 30
Protein class	Enzymes Plasma proteins Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in spermatids in testis.

ANTIBODY IHC RELIABILITY
Data reliability description	Presumed off target binding observed and disregarded.
Reliability score	Uncertain based on 1 antibody. HPA026080
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA026080

GENE INFORMATION
Gene name	ADAM30 (HGNC Symbol)
Synonyms	svph4
Description	ADAM metallopeptidase domain 30 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene is testis-specific and contains a polymorphic region, resulting in isoforms with varying numbers of C-terminal repeats. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p12
Chromosome location (bp)	119893533 - 119896495
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000134249 (version 83.38)
Entrez gene	11085
UniProt	Q9UKF2 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9UKF2
Antibodypedia	ADAM30 antibodies

PROTEIN BROWSER

ADAM30-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADAM30-001 ENSP00000358407 ENST00000369400	Q9UKF2 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 30 Show all	Enzymes Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0007338 [single fertilization] GO:0007339 [binding of sperm to zona pellucida] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] GO:0032504 [multicellular organism reproduction] Show all	790 aa 88.9 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.