Expression of VTCN1 in cancer - Summary - The Human Protein Atlas

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VTCN1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	VTCN1
Gene description	V-set domain containing T cell activation inhibitor 1
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (breast cancer, endometrial cancer, ovarian cancer)
HPA (cell line):	Group enriched (BEWO, SK-BR-3)
HPA (normal tissue):	Tissue enhanced (breast, fallopian tube)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membranous and cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA054200
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (breast cancer, endometrial cancer, ovarian cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

Pancreatic cancer

STAINING SUMMARY

HPA054200

GENE INFORMATION
Gene name	VTCN1 (HGNC Symbol)
Synonyms	B7-H4, B7H4, B7S1, B7X, FLJ22418
Description	V-set domain containing T cell activation inhibitor 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Chromosome	1
Cytoband
Chromosome location (bp)	117143587 - 117210960
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000134258 (version 83.38)
Entrez gene	79679
UniProt	Q7Z7D3 (UniProt - Evidence at protein level)
neXtProt	NX_Q7Z7D3
Antibodypedia	VTCN1 antibodies

PROTEIN BROWSER

VTCN1-001	VTCN1-002	VTCN1-201	VTCN1-202	VTCN1-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
VTCN1-001 ENSP00000358470 ENST00000369458	Q7Z7D3 [Direct mapping] V-set domain-containing T-cell activation inhibitor 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0001562 [response to protozoan] GO:0002250 [adaptive immune response] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0009897 [external side of plasma membrane] GO:0016021 [integral component of membrane] GO:0042102 [positive regulation of T cell proliferation] GO:0050868 [negative regulation of T cell activation] GO:0072602 [interleukin-4 secretion] GO:0072643 [interferon-gamma secretion] GO:1900042 [positive regulation of interleukin-2 secretion] Show all	282 aa 30.9 kDa	No	2
VTCN1-002 ENSP00000351899 ENST00000359008	Q5T2L0 [Direct mapping] V-set domain-containing T-cell activation inhibitor 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	285 aa 31.3 kDa	No	2
VTCN1-201 ENSP00000328168 ENST00000328189	Q7Z7D3 [Direct mapping] V-set domain-containing T-cell activation inhibitor 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0002250 [adaptive immune response] GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	166 aa 18.3 kDa	No	2
VTCN1-202 ENSP00000484316 ENST00000430871	A0A087X1M4 [Direct mapping] V-set domain-containing T-cell activation inhibitor 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	87 aa 9.8 kDa	No	1
VTCN1-203 ENSP00000444724 ENST00000539893	Q7Z7D3 [Direct mapping] V-set domain-containing T-cell activation inhibitor 1 Show all	Phobius predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0002250 [adaptive immune response] GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	187 aa 20.7 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.