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LDHA

GENERAL INFORMATION

Gene name

 LDHA

Gene description

 Lactate dehydrogenase A

Protein class

 Cancer-related genes
Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 12
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB015336
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable), lung cancer (unfavourable), pancreatic cancer (unfavourable) and cervical cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
Lung cancer p<0.001
Pancreatic cancer p<0.001
Cervical cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB015336

GENE INFORMATION

Gene name

 LDHA

Synonyms

Description

 Lactate dehydrogenase A (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Sep 2008]

Chromosome

 11

Cytoband

 p15.1

Chromosome location (bp)

 18394388 - 18408425

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000134333 (version 83.38)

Entrez gene

 3939

UniProt

 P00338 (UniProt - Evidence at protein level)

neXtProt

 NX_P00338

Antibodypedia

 LDHA antibodies

PROTEIN BROWSER
«
LDHA-001
LDHA-002
LDHA-003
LDHA-004
LDHA-005
LDHA-009
LDHA-010
LDHA-013
LDHA-014
LDHA-020
LDHA-201
LDHA-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LDHA-001
ENSP00000395337
ENST00000422447
P00338 [Direct mapping]
L-lactate dehydrogenase A chain
V9HWB9 [Target identity:100%; Query identity:100%]
L-lactate dehydrogenase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004459 [L-lactate dehydrogenase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006090 [pyruvate metabolic process]
GO:0006096 [glycolytic process]
GO:0016020 [membrane]
GO:0016491 [oxidoreductase activity]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0019752 [carboxylic acid metabolic process]
GO:0021762 [substantia nigra development]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 332 aa
36.7 kDa 		No 0
LDHA-002
ENSP00000379524
ENST00000396222
P00338 [Direct mapping]
L-lactate dehydrogenase A chain
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Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004459 [L-lactate dehydrogenase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006090 [pyruvate metabolic process]
GO:0006096 [glycolytic process]
GO:0016020 [membrane]
GO:0016491 [oxidoreductase activity]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0019752 [carboxylic acid metabolic process]
GO:0021762 [substantia nigra development]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 274 aa
30.1 kDa 		No 0
LDHA-003
ENSP00000227157
ENST00000227157
P00338 [Direct mapping]
L-lactate dehydrogenase A chain
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004459 [L-lactate dehydrogenase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006090 [pyruvate metabolic process]
GO:0006096 [glycolytic process]
GO:0016020 [membrane]
GO:0016491 [oxidoreductase activity]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0021762 [substantia nigra development]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 241 aa
26.7 kDa 		No 0
LDHA-004
ENSP00000446415
ENST00000495052
F5GXH2 [Direct mapping]
L-lactate dehydrogenase A chain
Show all
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016491 [oxidoreductase activity]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0019752 [carboxylic acid metabolic process]
GO:0055114 [oxidation-reduction process]
Show all
 114 aa
12.5 kDa 		No 0
LDHA-005
ENSP00000368722
ENST00000379412
P00338 [Direct mapping]
L-lactate dehydrogenase A chain
V9HWB9 [Target identity:100%; Query identity:100%]
L-lactate dehydrogenase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004459 [L-lactate dehydrogenase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006090 [pyruvate metabolic process]
GO:0006096 [glycolytic process]
GO:0016020 [membrane]
GO:0016491 [oxidoreductase activity]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0019752 [carboxylic acid metabolic process]
GO:0021762 [substantia nigra development]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 332 aa
36.7 kDa 		No 0
LDHA-009
ENSP00000441241
ENST00000478970
F5GYU2 [Direct mapping]
L-lactate dehydrogenase A chain
Show all
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016491 [oxidoreductase activity]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0019752 [carboxylic acid metabolic process]
GO:0055114 [oxidation-reduction process]
Show all
 144 aa
15.8 kDa 		No 0
LDHA-010
ENSP00000406172
ENST00000430553
P00338 [Direct mapping]
L-lactate dehydrogenase A chain
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004459 [L-lactate dehydrogenase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006090 [pyruvate metabolic process]
GO:0006096 [glycolytic process]
GO:0016020 [membrane]
GO:0016491 [oxidoreductase activity]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0019752 [carboxylic acid metabolic process]
GO:0021762 [substantia nigra development]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 274 aa
30.2 kDa 		No 0
LDHA-013
ENSP00000440161
ENST00000543445
F5GXY2 [Direct mapping]
L-lactate dehydrogenase A chain
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016491 [oxidoreductase activity]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0019752 [carboxylic acid metabolic process]
GO:0055114 [oxidation-reduction process]
Show all
 157 aa
17.4 kDa 		No 0
LDHA-014
ENSP00000444292
ENST00000535451
F5GZQ4 [Direct mapping]
L-lactate dehydrogenase A chain
Show all
   Phobius predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016491 [oxidoreductase activity]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0019752 [carboxylic acid metabolic process]
GO:0055114 [oxidation-reduction process]
Show all
 72 aa
7.9 kDa 		No 0
LDHA-020
ENSP00000445331
ENST00000542179
P00338 [Direct mapping]
L-lactate dehydrogenase A chain
V9HWB9 [Target identity:100%; Query identity:100%]
L-lactate dehydrogenase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004459 [L-lactate dehydrogenase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006090 [pyruvate metabolic process]
GO:0006096 [glycolytic process]
GO:0016020 [membrane]
GO:0016491 [oxidoreductase activity]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0019752 [carboxylic acid metabolic process]
GO:0021762 [substantia nigra development]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 332 aa
36.7 kDa 		No 0
LDHA-201
ENSP00000445175
ENST00000540430
P00338 [Direct mapping]
L-lactate dehydrogenase A chain
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0003824 [catalytic activity]
GO:0004457 [lactate dehydrogenase activity]
GO:0004459 [L-lactate dehydrogenase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006089 [lactate metabolic process]
GO:0006090 [pyruvate metabolic process]
GO:0006096 [glycolytic process]
GO:0007584 [response to nutrient]
GO:0009749 [response to glucose]
GO:0014070 [response to organic cyclic compound]
GO:0016020 [membrane]
GO:0016491 [oxidoreductase activity]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0019661 [glucose catabolic process to lactate via pyruvate]
GO:0019674 [NAD metabolic process]
GO:0019752 [carboxylic acid metabolic process]
GO:0019900 [kinase binding]
GO:0021762 [substantia nigra development]
GO:0031668 [cellular response to extracellular stimulus]
GO:0035686 [sperm fibrous sheath]
GO:0042493 [response to drug]
GO:0042542 [response to hydrogen peroxide]
GO:0042802 [identical protein binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043627 [response to estrogen]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0048569 [post-embryonic organ development]
GO:0051287 [NAD binding]
GO:0051591 [response to cAMP]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 361 aa
39.8 kDa 		No 0
LDHA-202
ENSP00000486249
ENST00000625635
F5GXU1 [Direct mapping]
L-lactate dehydrogenase A chain
Show all
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   TMHMM predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0019752 [carboxylic acid metabolic process]
GO:0055114 [oxidation-reduction process]
Show all
 46 aa
4.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.