Fields »
ABOUT
HELP
BLOG
CFHR4

GENERAL INFORMATION

Gene name

 CFHR4

Gene description

 Complement factor H-related 4

Protein class

 Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (liver cancer)
HPA (cell line):Cell line enhanced (U-266/70)
HPA (normal tissue):Tissue enriched (liver)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (favourable).
Liver cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 CFHR4 (HGNC Symbol)

Synonyms

 CFHL4, FHR-4, FHR4

Description

 Complement factor H-related 4 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the complement factor H (CFH) gene family, and encodes one of the 5 CFH-related (CFHR) proteins. These 5 genes are closely linked to the CFH gene on chromosome 1q31-q32. The CFHRs are secreted plasma proteins synthesized primarily by the hepatocytes, and composed of highly-related short consensus repeats (SCRs). This protein enhances the cofactor activity of CFH, and is involved in complement regulation. It can associate with lipoproteins and may play a role in lipid metabolism. Alternatively spliced transcript variants encoding different isoforms (varying in the number of SCRs) have been described for this gene. [provided by RefSeq, Jan 2011]

Chromosome

 1

Cytoband

 q31.3

Chromosome location (bp)

 196850241 - 196918972

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000134365 (version 83.38)

Entrez gene

 10877

UniProt

 Q92496 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92496

Antibodypedia

 CFHR4 antibodies

PROTEIN BROWSER
CFHR4-001
CFHR4-002
CFHR4-003
CFHR4-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CFHR4-001
ENSP00000356388
ENST00000367418
A0A0C4DH21 [Direct mapping]
Complement factor H-related protein 4
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 331 aa
37.3 kDa 		Yes 0
CFHR4-002
ENSP00000251424
ENST00000251424
Q92496 [Direct mapping]
Complement factor H-related protein 4
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005319 [lipid transporter activity]
GO:0005576 [extracellular region]
GO:0006869 [lipid transport]
Show all
 331 aa
37.3 kDa 		Yes 0
CFHR4-003
ENSP00000356386
ENST00000367416
Q92496 [Direct mapping]
Complement factor H-related protein 4
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005319 [lipid transporter activity]
GO:0005576 [extracellular region]
GO:0006869 [lipid transport]
Show all
 577 aa
65.2 kDa 		Yes 0
CFHR4-004
ENSP00000477162
ENST00000608469
V9GYX2 [Direct mapping]
Complement factor H-related protein 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 201 aa
22.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.