Expression of CFHR5 in cancer - Summary - The Human Protein Atlas

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CFHR5

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CFHR5
Gene description	Complement factor H-related 5
Protein class	Disease related genes Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (liver cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct positivity in plasma, extracellular matrix and proximal renal tubules.

ANTIBODY IHC RELIABILITY
Data reliability description	Caution, targets protein from more than one gene. Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Antibody staining in cells/structures not annotated, view images.
Reliability score	Supported based on 2 antibodies. HPA038915 , HPA040726
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA038915	HPA040726

GENE INFORMATION
Gene name	CFHR5 (HGNC Symbol)
Synonyms	CFHL5, FHR-5, FHR5
Description	Complement factor H-related 5 (HGNC Symbol)
Entrez gene summary	This gene is a member of a small complement factor H (CFH) gene cluster on chromosome 1. Each member of this gene family contains multiple short consensus repeats (SCRs) typical of regulators of complement activation. The protein encoded by this gene has nine SCRs with the first two repeats having heparin binding properties, a region within repeats 5-7 having heparin binding and C reactive protein binding properties, and the C-terminal repeats being similar to a complement component 3 b (C3b) binding domain. This protein co-localizes with C3, binds C3b in a dose-dependent manner, and is recruited to tissues damaged by C-reactive protein. Allelic variations in this gene have been associated, but not causally linked, with two different forms of kidney disease: membranoproliferative glomerulonephritis type II (MPGNII) and hemolytic uraemic syndrome (HUS). [provided by RefSeq, Jan 2010]
Chromosome	1
Cytoband	q31.3
Chromosome location (bp)	196977556 - 197009674
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000134389 (version 83.38)
Entrez gene	81494
UniProt	Q9BXR6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BXR6
Antibodypedia	CFHR5 antibodies

PROTEIN BROWSER

CFHR5-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CFHR5-001 ENSP00000256785 ENST00000256785	Q9BXR6 [Direct mapping] Complement factor H-related protein 5 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005576 [extracellular region] GO:0006957 [complement activation, alternative pathway] Show all	569 aa 64.4 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.