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RPS15A

GENERAL INFORMATION

Gene name

 RPS15A

Gene description

 Ribosomal protein S15a

Protein class

 Predicted intracellular proteins
Predicted membrane proteins
Ribosomal proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA047103
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA047103

GENE INFORMATION

Gene name

 RPS15A (HGNC Symbol)

Synonyms

 S15A

Description

 Ribosomal protein S15a (HGNC Symbol)

Entrez gene summary

 Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S8P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Chromosome

 16

Cytoband

 p12.3

Chromosome location (bp)

 18781295 - 18790383

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000134419 (version 83.38)

Entrez gene

 6210

UniProt

 P62244 (UniProt - Evidence at protein level)

neXtProt

 NX_P62244

Antibodypedia

 RPS15A antibodies

PROTEIN BROWSER
RPS15A-001
RPS15A-002
RPS15A-005
RPS15A-006
RPS15A-007
RPS15A-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RPS15A-001
ENSP00000318646
ENST00000322989
P62244 [Direct mapping]
40S ribosomal protein S15a
B2R4W8 [Target identity:100%; Query identity:100%]
HCG1994130, isoform CRA_a; cDNA FLJ30359 fis, clone BRACE2007760, highly similar to 40S RIBOSOMAL PROTEIN S15A; cDNA, FLJ92249, Homo sapiens ribosomal protein S15a (RPS15A), mRNA
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Ribosomal proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0003723 [RNA binding]
GO:0003735 [structural constituent of ribosome]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005840 [ribosome]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006414 [translational elongation]
GO:0006415 [translational termination]
GO:0006614 [SRP-dependent cotranslational protein targeting to membrane]
GO:0008284 [positive regulation of cell proliferation]
GO:0009615 [response to virus]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0022627 [cytosolic small ribosomal subunit]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045787 [positive regulation of cell cycle]
GO:0070062 [extracellular exosome]
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 130 aa
14.8 kDa 		No 0
RPS15A-002
ENSP00000457000
ENST00000563390
P62244 [Direct mapping]
40S ribosomal protein S15a
B2R4W8 [Target identity:100%; Query identity:100%]
HCG1994130, isoform CRA_a; cDNA FLJ30359 fis, clone BRACE2007760, highly similar to 40S RIBOSOMAL PROTEIN S15A; cDNA, FLJ92249, Homo sapiens ribosomal protein S15a (RPS15A), mRNA
Show all
Ribosomal proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0003723 [RNA binding]
GO:0003735 [structural constituent of ribosome]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005840 [ribosome]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006414 [translational elongation]
GO:0006415 [translational termination]
GO:0006614 [SRP-dependent cotranslational protein targeting to membrane]
GO:0008284 [positive regulation of cell proliferation]
GO:0009615 [response to virus]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0022627 [cytosolic small ribosomal subunit]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045787 [positive regulation of cell cycle]
GO:0070062 [extracellular exosome]
Show all
 130 aa
14.8 kDa 		No 0
RPS15A-005
ENSP00000458115
ENST00000565420
P62244 [Direct mapping]
40S ribosomal protein S15a
B2R4W8 [Target identity:100%; Query identity:100%]
HCG1994130, isoform CRA_a; cDNA FLJ30359 fis, clone BRACE2007760, highly similar to 40S RIBOSOMAL PROTEIN S15A; cDNA, FLJ92249, Homo sapiens ribosomal protein S15a (RPS15A), mRNA
Show all
Ribosomal proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0003723 [RNA binding]
GO:0003735 [structural constituent of ribosome]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005840 [ribosome]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006414 [translational elongation]
GO:0006415 [translational termination]
GO:0006614 [SRP-dependent cotranslational protein targeting to membrane]
GO:0008284 [positive regulation of cell proliferation]
GO:0009615 [response to virus]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0022627 [cytosolic small ribosomal subunit]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045787 [positive regulation of cell cycle]
GO:0070062 [extracellular exosome]
Show all
 130 aa
14.8 kDa 		No 0
RPS15A-006
ENSP00000460618
ENST00000569083
I3L3P7 [Direct mapping]
40S ribosomal protein S15a
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003735 [structural constituent of ribosome]
GO:0005840 [ribosome]
GO:0006412 [translation]
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 100 aa
11.5 kDa 		No 0
RPS15A-007
ENSP00000458052
ENST00000563579
H3BVC7 [Direct mapping]
40S ribosomal protein S15a
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
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GO:0003735 [structural constituent of ribosome]
GO:0005840 [ribosome]
GO:0006412 [translation]
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 58 aa
6.7 kDa 		No 1
RPS15A-012
ENSP00000459554
ENST00000576436
I3L246 [Direct mapping]
40S ribosomal protein S15a
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003735 [structural constituent of ribosome]
GO:0005840 [ribosome]
GO:0006412 [translation]
Show all
 111 aa
12.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.