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NARS

GENERAL INFORMATION

Gene name

 NARS

Gene description

 Asparaginyl-tRNA synthetase

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 2 antibodies.
HPA040017 , CAB034257
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and renal cancer (favourable).
Liver cancer p<0.001
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA040017
CAB034257

GENE INFORMATION

Gene name

 NARS (HGNC Symbol)

Synonyms

 NARS1

Description

 Asparaginyl-tRNA synthetase (HGNC Symbol)

Entrez gene summary

 Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Asparaginyl-tRNA synthetase is localized to the cytoplasm and belongs to the class II family of tRNA synthetases. The N-terminal domain represents the signature sequence for the eukaryotic asparaginyl-tRNA synthetases. [provided by RefSeq, Jul 2008]

Chromosome

 18

Cytoband

 q21.31

Chromosome location (bp)

 57600656 - 57622213

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000134440 (version 83.38)

Entrez gene

 4677

UniProt

 O43776 (UniProt - Evidence at protein level)

neXtProt

 NX_O43776

Antibodypedia

 NARS antibodies

PROTEIN BROWSER
NARS-001
NARS-005
NARS-006
NARS-007
NARS-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NARS-001
ENSP00000256854
ENST00000256854
O43776 [Direct mapping]
Asparagine--tRNA ligase, cytoplasmic
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Enzymes
   ENZYME proteins
   Ligase
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004816 [asparagine-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006421 [asparaginyl-tRNA aminoacylation]
GO:0010467 [gene expression]
GO:0070062 [extracellular exosome]
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 548 aa
62.9 kDa 		No 0
NARS-005
ENSP00000466606
ENST00000587675
K7EMQ6 [Direct mapping]
Asparagine--tRNA ligase, cytoplasmic
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0004816 [asparagine-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006421 [asparaginyl-tRNA aminoacylation]
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 128 aa
14.6 kDa 		No 0
NARS-006
ENSP00000467421
ENST00000588661
K7EPK2 [Direct mapping]
Asparagine--tRNA ligase, cytoplasmic
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0004816 [asparagine-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006421 [asparaginyl-tRNA aminoacylation]
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 163 aa
18.7 kDa 		No 0
NARS-007
ENSP00000467651
ENST00000591599
K7EQ35 [Direct mapping]
Asparagine--tRNA ligase, cytoplasmic
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0004816 [asparagine-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006421 [asparaginyl-tRNA aminoacylation]
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 167 aa
18.9 kDa 		No 0
NARS-008
ENSP00000464899
ENST00000587194
K7EIU7 [Direct mapping]
Asparagine--tRNA ligase, cytoplasmic
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004816 [asparagine-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006421 [asparaginyl-tRNA aminoacylation]
Show all
 162 aa
18.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.