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FBXO18

GENERAL INFORMATION

Gene name

 FBXO18

Gene description

 F-box protein, helicase, 18

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA002844
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Ovary
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Fallopian tube

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 FBXO18 (HGNC Symbol)

Synonyms

 FBH1, Fbx18, FLJ14590

Description

 F-box protein, helicase, 18 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. It contains an F-box motif and seven conserved helicase motifs, and has both DNA-dependent ATPase and DNA unwinding activities. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 10

Cytoband

 p15.1

Chromosome location (bp)

 5890203 - 5937594

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000134452 (version 83.38)

Entrez gene

 84893

UniProt

 Q8NFZ0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8NFZ0

Antibodypedia

 FBXO18 antibodies

PROTEIN BROWSER
FBXO18-009
FBXO18-010
FBXO18-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FBXO18-009
ENSP00000355415
ENST00000362091
Q8NFZ0 [Direct mapping]
F-box DNA helicase 1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000737 [DNA catabolic process, endonucleolytic]
GO:0000785 [chromatin]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0003678 [DNA helicase activity]
GO:0003690 [double-stranded DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0004003 [ATP-dependent DNA helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0008219 [cell death]
GO:0015616 [DNA translocase activity]
GO:0016567 [protein ubiquitination]
GO:0016787 [hydrolase activity]
GO:0019005 [SCF ubiquitin ligase complex]
GO:0031297 [replication fork processing]
GO:0032508 [DNA duplex unwinding]
GO:0043138 [3'-5' DNA helicase activity]
GO:0048478 [replication fork protection]
GO:0072429 [response to intra-S DNA damage checkpoint signaling]
GO:1902231 [positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage]
GO:2000042 [negative regulation of double-strand break repair via homologous recombination]
Show all
 1043 aa
117.7 kDa 		No 1
FBXO18-010
ENSP00000369335
ENST00000379999
Q8NFZ0 [Direct mapping]
F-box DNA helicase 1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000737 [DNA catabolic process, endonucleolytic]
GO:0000785 [chromatin]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0003678 [DNA helicase activity]
GO:0003690 [double-stranded DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0004003 [ATP-dependent DNA helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0008219 [cell death]
GO:0015616 [DNA translocase activity]
GO:0016567 [protein ubiquitination]
GO:0016787 [hydrolase activity]
GO:0019005 [SCF ubiquitin ligase complex]
GO:0031297 [replication fork processing]
GO:0032508 [DNA duplex unwinding]
GO:0035562 [negative regulation of chromatin binding]
GO:0043138 [3'-5' DNA helicase activity]
GO:0048478 [replication fork protection]
GO:0072429 [response to intra-S DNA damage checkpoint signaling]
GO:1902231 [positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage]
GO:2000042 [negative regulation of double-strand break repair via homologous recombination]
Show all
 1094 aa
123.4 kDa 		No 1
FBXO18-201
ENSP00000380439
ENST00000397269
F6UZG9 [Direct mapping]
F-box only protein 18; F-box protein, helicase, 18, isoform CRA_b
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0004003 [ATP-dependent DNA helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0008152 [metabolic process]
GO:0016787 [hydrolase activity]
GO:0032508 [DNA duplex unwinding]
Show all
 986 aa
110.9 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.