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Cancer-related genes CD markers Disease related genes FDA approved drug targets Plasma proteins Predicted intracellular proteins Predicted membrane proteins
A fraction of tumor cells in a few cases of gliomas and in a single case of mucinous cystadenocarcinoma of ovary showed strong cytoplasmic staining. A single case of lobular carcinoma of breast and colorectal cancer displayed moderate positivity. Remaining cancer tissues were negative.
Few cases of lymphomas and colorectal cancers, which showed weak to moderate cytoplasmic staining. Remaining cancer tissues were negative.
GENE INFORMATION
Gene name
IL2RA (HGNC Symbol)
Synonyms
CD25, IDDM10, IL2R
Description
Interleukin 2 receptor, alpha (HGNC Symbol)
Entrez gene summary
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009]