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CCNH

GENERAL INFORMATION

Gene name

 CCNH

Gene description

 Cyclin H

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB019416
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and ovarian cancer (unfavourable).
Renal cancer p<0.001
Ovarian cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Urothelial cancer

STAINING SUMMARY
CAB019416

GENE INFORMATION

Gene name

 CCNH (HGNC Symbol)

Synonyms

 CycH, p34, p37

Description

 Cyclin H (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery. A pseudogene of this gene is found on chromosome 4. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Nov 2010]

Chromosome

 5

Cytoband

 q14.3

Chromosome location (bp)

 87391494 - 87413019

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000134480 (version 83.38)

Entrez gene

 902

UniProt

 P51946 (UniProt - Evidence at protein level)

neXtProt

 NX_P51946

Antibodypedia

 CCNH antibodies

PROTEIN BROWSER
CCNH-001
CCNH-002
CCNH-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CCNH-001
ENSP00000256897
ENST00000256897
P51946 [Direct mapping]
Cyclin-H
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005675 [holo TFIIH complex]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006351 [transcription, DNA-templated]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006361 [transcription initiation from RNA polymerase I promoter]
GO:0006362 [transcription elongation from RNA polymerase I promoter]
GO:0006363 [termination of RNA polymerase I transcription]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0006370 [7-methylguanosine mRNA capping]
GO:0006468 [protein phosphorylation]
GO:0008094 [DNA-dependent ATPase activity]
GO:0008353 [RNA polymerase II carboxy-terminal domain kinase activity]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0016301 [kinase activity]
GO:0016538 [cyclin-dependent protein serine/threonine kinase regulator activity]
GO:0019901 [protein kinase binding]
GO:0019907 [cyclin-dependent protein kinase activating kinase holoenzyme complex]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050434 [positive regulation of viral transcription]
GO:0070911 [global genome nucleotide-excision repair]
GO:0070985 [TFIIK complex]
GO:1901409 [positive regulation of phosphorylation of RNA polymerase II C-terminal domain]
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 323 aa
37.6 kDa 		No 0
CCNH-002
ENSP00000426075
ENST00000504878
D6RHI7 [Direct mapping]
Cyclin-H
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0016538 [cyclin-dependent protein serine/threonine kinase regulator activity]
GO:0019901 [protein kinase binding]
GO:0070985 [TFIIK complex]
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 249 aa
28.9 kDa 		No 0
CCNH-003
ENSP00000426454
ENST00000508855
D6RG18 [Direct mapping]
Cyclin-H
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0016538 [cyclin-dependent protein serine/threonine kinase regulator activity]
GO:0019901 [protein kinase binding]
GO:0070985 [TFIIK complex]
Show all
 255 aa
29.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.