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SLCO1B1

GENERAL INFORMATION

Gene name

 SLCO1B1

Gene description

 Solute carrier organic anion transporter family, member 1B1

Protein class

 Disease related genes
Plasma proteins
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (liver cancer)
HPA (cell line):Not detected
HPA (normal tissue):Tissue enriched (liver)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective membranous staining in hepatocytes.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 1 antibody.
HPA050892
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA050892

GENE INFORMATION

Gene name

 SLCO1B1 (HGNC Symbol)

Synonyms

 LST-1, OATP-C, OATP1B1, SLC21A6

Description

 Solute carrier organic anion transporter family, member 1B1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and leukotriene C4. This protein is also involved in the removal of drug compounds such as statins, bromosulfophthalein and rifampin from the blood into the hepatocytes. Polymorphisms in the gene encoding this protein are associated with impaired transporter function. [provided by RefSeq, Mar 2009]

Chromosome

 12

Cytoband

 p12.1

Chromosome location (bp)

 21131202 - 21239246

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000134538 (version 83.38)

Entrez gene

 10599

UniProt

 Q9Y6L6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y6L6

Antibodypedia

 SLCO1B1 antibodies

PROTEIN BROWSER
SLCO1B1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLCO1B1-001
ENSP00000256958
ENST00000256958
Q9Y6L6 [Direct mapping]
Solute carrier organic anion transporter family member 1B1
A0A024RAU7 [Target identity:100%; Query identity:100%]
Solute carrier organic anion transporter family member
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Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
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GO:0005215 [transporter activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0008206 [bile acid metabolic process]
GO:0015125 [bile acid transmembrane transporter activity]
GO:0015347 [sodium-independent organic anion transmembrane transporter activity]
GO:0015711 [organic anion transport]
GO:0015721 [bile acid and bile salt transport]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0043252 [sodium-independent organic anion transport]
GO:0044281 [small molecule metabolic process]
GO:0055085 [transmembrane transport]
GO:0098656 [anion transmembrane transport]
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 691 aa
76.4 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.