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DDB2

GENERAL INFORMATION

Gene name

 DDB2

Gene description

 Damage-specific DNA binding protein 2, 48kDa

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear expression, most abundant in squamous epithelium.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA058406 , CAB025912
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable), cervical cancer (favourable) and breast cancer (favourable).
Endometrial cancer p<0.001
Cervical cancer p<0.001
Breast cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA058406
CAB025912

GENE INFORMATION

Gene name

 DDB2 (HGNC Symbol)

Synonyms

 DDBB, FLJ34321, UV-DDB2, XPE

Description

 Damage-specific DNA binding protein 2, 48kDa (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

Chromosome

 11

Cytoband

 p11.2

Chromosome location (bp)

 47214465 - 47239240

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000134574 (version 83.38)

Entrez gene

 1643

UniProt

 Q92466 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92466

Antibodypedia

 DDB2 antibodies

PROTEIN BROWSER
DDB2-001
DDB2-006
DDB2-007
DDB2-011
DDB2-012
DDB2-013

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DDB2-001
ENSP00000256996
ENST00000256996
Q92466 [Direct mapping]
DNA damage-binding protein 2
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Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0000715 [nucleotide-excision repair, DNA damage recognition]
GO:0003677 [DNA binding]
GO:0003684 [damaged DNA binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0006281 [DNA repair]
GO:0006289 [nucleotide-excision repair]
GO:0006290 [pyrimidine dimer repair]
GO:0009411 [response to UV]
GO:0030054 [cell junction]
GO:0031465 [Cul4B-RING E3 ubiquitin ligase complex]
GO:0033683 [nucleotide-excision repair, DNA incision]
GO:0035518 [histone H2A monoubiquitination]
GO:0043234 [protein complex]
GO:0051865 [protein autoubiquitination]
GO:0070911 [global genome nucleotide-excision repair]
GO:0070914 [UV-damage excision repair]
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 427 aa
47.9 kDa 		No 0
DDB2-006
ENSP00000367863
ENST00000378600
Q92466 [Direct mapping]
DNA damage-binding protein 2
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0000715 [nucleotide-excision repair, DNA damage recognition]
GO:0003677 [DNA binding]
GO:0003684 [damaged DNA binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0006281 [DNA repair]
GO:0006289 [nucleotide-excision repair]
GO:0009411 [response to UV]
GO:0030054 [cell junction]
GO:0031465 [Cul4B-RING E3 ubiquitin ligase complex]
GO:0033683 [nucleotide-excision repair, DNA incision]
GO:0035518 [histone H2A monoubiquitination]
GO:0043234 [protein complex]
GO:0051865 [protein autoubiquitination]
GO:0070911 [global genome nucleotide-excision repair]
GO:0070914 [UV-damage excision repair]
Show all
 238 aa
26.7 kDa 		No 0
DDB2-007
ENSP00000367866
ENST00000378603
Q92466 [Direct mapping]
DNA damage-binding protein 2
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0000715 [nucleotide-excision repair, DNA damage recognition]
GO:0003677 [DNA binding]
GO:0003684 [damaged DNA binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0006281 [DNA repair]
GO:0006289 [nucleotide-excision repair]
GO:0009411 [response to UV]
GO:0030054 [cell junction]
GO:0031465 [Cul4B-RING E3 ubiquitin ligase complex]
GO:0033683 [nucleotide-excision repair, DNA incision]
GO:0035518 [histone H2A monoubiquitination]
GO:0043234 [protein complex]
GO:0051865 [protein autoubiquitination]
GO:0070911 [global genome nucleotide-excision repair]
GO:0070914 [UV-damage excision repair]
Show all
 363 aa
40.8 kDa 		No 0
DDB2-011
ENSP00000479196
ENST00000622878
A0A087WV56 [Direct mapping]
DNA damage-binding protein 2
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
 93 aa
10.4 kDa 		No 0
DDB2-012
ENSP00000483718
ENST00000614825
A0A087X0X5 [Direct mapping]
DNA damage-binding protein 2
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 228 aa
25.1 kDa 		No 0
DDB2-013
ENSP00000479994
ENST00000622090
A0A087WW71 [Direct mapping]
DNA damage-binding protein 2
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 163 aa
17.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.