Expression of GNL2 in cancer - Summary - The Human Protein Atlas

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GNL2

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GNL2
Gene description	Guanine nucleotide binding protein-like 2 (nucleolar)
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nucleolar expression in several different tissue types.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA027163
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable) and ovarian cancer (favourable).
Renal cancer p<0.001 Liver cancer p<0.001 Ovarian cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA027163

GENE INFORMATION
Gene name	GNL2 (HGNC Symbol)
Synonyms	HUMAUANTIG, Ngp-1, Nog2, Nug2
Description	Guanine nucleotide binding protein-like 2 (nucleolar) (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	p34.3
Chromosome location (bp)	37566816 - 37595935
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000134697 (version 83.38)
Entrez gene	29889
UniProt	Q13823 (UniProt - Evidence at protein level)
neXtProt	NX_Q13823
Antibodypedia	GNL2 antibodies

PROTEIN BROWSER

GNL2-001	GNL2-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GNL2-001 ENSP00000362153 ENST00000373062	Q13823 [Direct mapping] Nucleolar GTP-binding protein 2 Q5T0F3 [Target identity:100%; Query identity:100%] Guanine nucleotide binding protein-like 2 (Nucleolar); cDNA, FLJ93364, Homo sapiens nucleolar GTPase (HUMAUANTIG), mRNA Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003924 [GTPase activity] GO:0005525 [GTP binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0008150 [biological_process] GO:0016020 [membrane] GO:0042254 [ribosome biogenesis] GO:0044822 [poly(A) RNA binding] Show all	731 aa 83.7 kDa	No	0
GNL2-004 ENSP00000441288 ENST00000538069	H0YG10 [Direct mapping] Nucleolar GTP-binding protein 2 Show all	Phobius predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003924 [GTPase activity] GO:0005525 [GTP binding] GO:0005730 [nucleolus] GO:0016021 [integral component of membrane] GO:0042254 [ribosome biogenesis] Show all	233 aa 26.1 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.