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Most ovarian, endometrial and breast cancers along with a few lung and urothelial cancers showed moderate to strong cytoplasmic and/or membranous positivity. Malignant cells in general were negative.
This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic containing PAZ and PIWI domains, and it may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a cluster of closely related family members including argonaute 3, and eukaryotic translation initiation factor 2C, 1. [provided by RefSeq, Jul 2008]