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HOOK1

GENERAL INFORMATION

Gene name

 HOOK1

Gene description

 Hook microtubule-tethering protein 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (EFO-21)
HPA (normal tissue):Tissue enhanced (parathyroid gland)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective cytoplasmic expression in spermatids.

ANTIBODY IHC RELIABILITY

Data reliability
description

 External characterization data supports antibody staining. Paired antibodies with high similarity supports the protein expression profile.

Reliability score

 Supported based on 2 antibodies.
HPA018537 , HPA018820
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PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (favourable) and head and neck cancer (favourable).
Colorectal cancer p<0.001
Head and neck cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA018537
HPA018820

GENE INFORMATION

Gene name

 HOOK1 (HGNC Symbol)

Synonyms

 HK1

Description

 Hook microtubule-tethering protein 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the hook family of coiled-coil proteins, which bind to microtubules and organelles through their N- and C-terminal domains, respectively. The encoded protein localizes to discrete punctuate subcellular structures, and interacts with several members of the Rab GTPase family involved in endocytosis. It is thought to link endocytic membrane trafficking to the microtubule cytoskeleton. Several alternatively spliced transcript variants have been identified, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p32.1

Chromosome location (bp)

 59814786 - 59876378

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000134709 (version 83.38)

Entrez gene

 51361

UniProt

 Q9UJC3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UJC3

Antibodypedia

 HOOK1 antibodies

PROTEIN BROWSER
HOOK1-001
HOOK1-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HOOK1-001
ENSP00000360252
ENST00000371208
Q9UJC3 [Direct mapping]
Protein Hook homolog 1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005874 [microtubule]
GO:0007032 [endosome organization]
GO:0007040 [lysosome organization]
GO:0007275 [multicellular organismal development]
GO:0007286 [spermatid development]
GO:0008333 [endosome to lysosome transport]
GO:0015031 [protein transport]
GO:0015630 [microtubule cytoskeleton]
GO:0030897 [HOPS complex]
GO:0042802 [identical protein binding]
GO:0045022 [early endosome to late endosome transport]
GO:0070695 [FHF complex]
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 728 aa
84.6 kDa 		No 0
HOOK1-003
ENSP00000398860
ENST00000455990
B1AK95 [Direct mapping]
Protein Hook homolog 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 137 aa
15.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.