Expression of ZCCHC11 in cancer - Summary

GENERAL INFORMATION
Gene name	ZCCHC11
Gene description	Zinc finger, CCHC domain containing 11
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct expression in smooth muscle and endothelium while most other tissues showed weaker expression or were negative.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA027412 , HPA027973
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA027412	HPA027973

GENE INFORMATION
Gene name	ZCCHC11 (HGNC Symbol)
Synonyms	KIAA0191, PAPD3, TUT4
Description	Zinc finger, CCHC domain containing 11 (HGNC Symbol)
Entrez gene summary	ZCCHC11 is an RNA uridyltransferase (EC 2.7.7.52) that uses UTP to add uridines to the 3-prime end of substrate RNA molecules (Jones et al., 2009 [PubMed 19701194]).[supplied by OMIM, Jan 2011]
Chromosome	1
Cytoband	p32.3
Chromosome location (bp)	52408282 - 52553487
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000134744 (version 83.38)
Entrez gene	23318
UniProt	Q5TAX3 (UniProt - Evidence at protein level)
neXtProt	NX_Q5TAX3
Antibodypedia	ZCCHC11 antibodies

PROTEIN BROWSER

ZCCHC11-001	ZCCHC11-003	ZCCHC11-005	ZCCHC11-007	ZCCHC11-012	ZCCHC11-013	ZCCHC11-015	ZCCHC11-016	ZCCHC11-017	ZCCHC11-018	ZCCHC11-019	ZCCHC11-021

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZCCHC11-001 ENSP00000360599 ENST00000371544	Q5TAX3 [Direct mapping] Terminal uridylyltransferase 4 Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0008270 [zinc ion binding] GO:0010586 [miRNA metabolic process] GO:0010587 [miRNA catabolic process] GO:0016779 [nucleotidyltransferase activity] GO:0019827 [stem cell population maintenance] GO:0031054 [pre-miRNA processing] GO:0031123 [RNA 3'-end processing] GO:0044822 [poly(A) RNA binding] GO:0050265 [RNA uridylyltransferase activity] GO:0070062 [extracellular exosome] Show all	1644 aa 185.2 kDa	No	0
ZCCHC11-003 ENSP00000348063 ENST00000355809	X6R5G7 [Direct mapping] Terminal uridylyltransferase 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		309 aa 34.1 kDa	No	0
ZCCHC11-005 ENSP00000257177 ENST00000257177	A0A0C4DFM7 [Direct mapping] Terminal uridylyltransferase 4 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001816 [cytokine production] GO:0003676 [nucleic acid binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0008270 [zinc ion binding] GO:0010586 [miRNA metabolic process] GO:0016779 [nucleotidyltransferase activity] GO:0031664 [regulation of lipopolysaccharide-mediated signaling pathway] GO:0032088 [negative regulation of NF-kappaB transcription factor activity] GO:0032755 [positive regulation of interleukin-6 production] GO:0070102 [interleukin-6-mediated signaling pathway] Show all	1645 aa 185.3 kDa	No	0
ZCCHC11-007 ENSP00000437091 ENST00000494469	H0YF28 [Direct mapping] Terminal uridylyltransferase 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		151 aa 16.4 kDa	No	0
ZCCHC11-012 ENSP00000433486 ENST00000528642	E9PKY2 [Direct mapping] Terminal uridylyltransferase 4 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0008152 [metabolic process] GO:0008270 [zinc ion binding] GO:0016779 [nucleotidyltransferase activity] Show all	1203 aa 136 kDa	No	0
ZCCHC11-013 ENSP00000434367 ENST00000470626	E9PQS7 [Direct mapping] Terminal uridylyltransferase 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		87 aa 9.7 kDa	No	0
ZCCHC11-015 ENSP00000434674 ENST00000471623	H0YDZ6 [Direct mapping] Terminal uridylyltransferase 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		105 aa 11.7 kDa	No	0
ZCCHC11-016 ENSP00000433711 ENST00000474453	H0YDJ1 [Direct mapping] Terminal uridylyltransferase 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0008270 [zinc ion binding] Show all	337 aa 38.3 kDa	No	0
ZCCHC11-017 ENSP00000435256 ENST00000484723	E9PKX1 [Direct mapping] Terminal uridylyltransferase 4 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0008152 [metabolic process] GO:0008270 [zinc ion binding] GO:0016779 [nucleotidyltransferase activity] Show all	906 aa 103.2 kDa	No	0
ZCCHC11-018 ENSP00000435568 ENST00000524582	E9PJN7 [Direct mapping] Terminal uridylyltransferase 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		77 aa 8.7 kDa	No	0
ZCCHC11-019 ENSP00000435700 ENST00000531722	H0YEE8 [Direct mapping] Terminal uridylyltransferase 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0008270 [zinc ion binding] Show all	338 aa 38 kDa	No	0
ZCCHC11-021 ENSP00000432475 ENST00000528457	H0YCX5 [Direct mapping] Terminal uridylyltransferase 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		164 aa 18.2 kDa	No	0