Expression of DSC3 in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	DSC3
Gene description	Desmocollin 3
Protein class	Disease related genes Plasma proteins Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (cervical cancer, head and neck cancer)
HPA (cell line):	Cell line enhanced (HaCaT, hTCEpi, REH)
HPA (normal tissue):	Group enriched (esophagus, skin)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cellmembranous expression in squamous epithelia and cytoplasmic expression in placenta.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA049265 , CAB037328
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (unfavourable).
Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (cervical cancer, head and neck cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA049265	CAB037328

GENE INFORMATION
Gene name	DSC3 (HGNC Symbol)
Synonyms	CDHF3, DSC, DSC1, DSC2, DSC4
Description	Desmocollin 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are a cause of hypotrichosis and recurrent skin vesicles disorder. The protein can act as an autoantigen in pemphigus diseases, and it is also considered to be a biomarker for some cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Chromosome	18
Cytoband	q12.1
Chromosome location (bp)	30990008 - 31042815
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000134762 (version 83.38)
Entrez gene	1825
UniProt	Q14574 (UniProt - Evidence at protein level)
neXtProt	NX_Q14574
Antibodypedia	DSC3 antibodies

PROTEIN BROWSER

DSC3-001	DSC3-002	DSC3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DSC3-001 ENSP00000353608 ENST00000360428	Q14574 [Direct mapping] Desmocollin-3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001701 [in utero embryonic development] GO:0005509 [calcium ion binding] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005911 [cell-cell junction] GO:0007155 [cell adhesion] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030057 [desmosome] GO:0045295 [gamma-catenin binding] GO:0050821 [protein stabilization] Show all	896 aa 100 kDa	Yes	1
DSC3-002 ENSP00000464283 ENST00000584980	J3QRL9 [Direct mapping] Desmocollin-3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0016021 [integral component of membrane] Show all	214 aa 23 kDa	No	1
DSC3-201 ENSP00000392068 ENST00000434452	Q14574 [Direct mapping] Desmocollin-3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005886 [plasma membrane] GO:0005911 [cell-cell junction] GO:0007155 [cell adhesion] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030057 [desmosome] GO:0045295 [gamma-catenin binding] GO:0050821 [protein stabilization] Show all	839 aa 93.5 kDa	Yes	1